KEGG   DRUG: DarodipineHelp
Entry
D03655                      Drug                                   

Name
Darodipine (USAN/INN)
Formula
C19H21N3O5
Exact mass
371.1481
Mol weight
371.3871
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Efficacy
Antihypertensive, Bronchodilator, Vasodilator, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D03655  Darodipine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 72803-02-2
PubChem: 17397752
ChEMBL: CHEMBL2104154
LigandBox: D03655
NIKKAJI: J22.967I
LinkDB All DBs
KCF data Show

ATOM        27
            1   C1y C     9.7763   -6.4487
            2   C2y C    10.9861   -5.7370
            3   C2y C     8.5665   -5.7370
            4   C8y C     9.7763   -8.8682
            5   C2y C    10.9861   -4.3849
            6   C7a C    12.1958   -6.4487
            7   C2y C     8.5665   -4.3849
            8   C7a C     7.4279   -6.3775
            9   C8x C    10.9861   -9.5798
            10  C8y C     8.5665   -9.5798
            11  N1x N     9.7763   -3.6733
            12  C1a C    12.1958   -3.6733
            13  O7a O    13.3345   -5.7370
            14  O6a O    12.1958   -7.8008
            15  C1a C     7.4279   -3.6733
            16  O7a O     6.2182   -5.7370
            17  O6a O     7.4279   -7.8008
            18  C8x C    10.9861  -10.8608
            19  C8y C     8.5665  -10.8608
            20  C1b C    14.5442   -6.4487
            21  C1b C     5.0084   -6.3775
            22  C8x C     9.7763  -11.5724
            23  C1a C    15.7826   -5.7471
            24  N5x N     7.3483   -9.1840
            25  O2x O     6.5953  -10.2203
            26  N5x N     7.3483  -11.2566
            27  C1a C     3.8421   -5.6454
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   13  20 1
            20   16  21 1
            21   18  22 2
            22    7  11 1
            23   19  22 1
            24   20  23 1
            25   10  24 2
            26   24  25 1
            27   25  26 1
            28   19  26 2
            29   21  27 1

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