KEGG   DRUG: Desonide
Entry
D03696                      Drug                                   

Name
Desonide (USP/INN);
Desowen (TN);
Verdeso (TN)
Product
  Generic
DESONIDE (Actavis Pharma), DESONIDE (Alembic Pharmaceuticals), DESONIDE (Alembic Pharmaceuticals), DESONIDE (Aleor Dermaceuticals Limited), DESONIDE (Aleor Dermaceuticals Limited), DESONIDE (Amneal Pharmaceuticals of New York LLC), DESONIDE (Cadila Healthcare Limited), DESONIDE (Cintex Services), DESONIDE (Cosette Pharmaceuticals), DESONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (Glenmark Pharmaceuticals), DESONIDE (NORTHSTAR RX LLC), DESONIDE (Northstar Rx LLC), DESONIDE (Proficient Rx LP), DESONIDE (Taro Pharmaceuticals U.S.A.), DESONIDE (Taro Pharmaceuticals U.S.A.), DESONIDE (Teligent Pharma), DESONIDE (Versapharm Incorporated), DESONIDE (Viona Pharmaceuticals), DESONIDE (Zydus Pharmaceuticals (USA)), DESONIDE OINTMENT, 0.05% (Encube Ethicals Private Limited)
Formula
C24H32O6
Exact mass
416.2199
Mol weight
416.5073
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: D07AB08 S01BA11
Product: D03696<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB08 Desonide
      D03696  Desonide (USP/INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA11 Desonide
      D03696  Desonide (USP/INN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Desonide
     D03696  Desonide (USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03696  Desonide (USP/INN) <US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D03696
Other DBs
CAS: 638-94-8
PubChem: 17397789
ChEBI: 204734
ChEMBL: CHEMBL1201109 CHEMBL1871261
DrugBank: DB01260
LigandBox: D03696
NIKKAJI: J6.927B
LinkDB
KCF data

ATOM        30
            1   C2x C    29.0870  -20.6780
            2   C5x C    29.0870  -22.0509
            3   C2x C    30.2760  -22.7374
            4   C2y C    31.4650  -22.0509
            5   C1z C    31.4650  -20.6780
            6   C2x C    30.2760  -19.9916
            7   C1x C    32.6539  -22.7374
            8   C1x C    33.8429  -22.0509
            9   C1y C    33.8429  -20.6780
            10  C1y C    32.6539  -19.9916
            11  C1y C    35.0319  -19.9916
            12  C1z C    35.0319  -18.6187
            13  C1x C    33.8429  -17.9322
            14  C1y C    32.6539  -18.6187
            15  C1x C    37.4098  -19.9916
            16  C1y C    37.4098  -18.6187
            17  C1z C    36.2208  -17.9322
            18  O2x O    38.7827  -18.6187
            19  C1z C    38.7827  -17.2458
            20  C1a C    38.7827  -15.8728
            21  O2x O    37.4098  -17.2458
            22  C1a C    40.1556  -17.2458
            23  C5a C    36.2208  -16.2793
            24  O5a O    37.4138  -15.5906
            25  C1b C    35.0358  -15.5951
            26  O5x O    27.8981  -22.7374
            27  C1a C    31.4650  -19.3051
            28  O1a O    31.4670  -17.9334
            29  C1a C    35.0319  -17.2458
            30  O1a O    33.8431  -16.2843
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   16  18 1 #Down
            22   18  19 1
            23   19  20 1
            24   17  21 1 #Down
            25   21  19 1
            26   19  22 1
            27   17  23 1 #Up
            28   23  24 2
            29   23  25 1
            30    2  26 2
            31    5  27 1 #Up
            32   14  28 1 #Up
            33   12  29 1 #Up
            34   25  30 1

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