KEGG   DRUG: Englitazone sodium
Entry
D03996                      Drug                                   

Name
Englitazone sodium (USAN)
Formula
C20H18NO3S. Na
Exact mass
375.0905
Mol weight
375.4166
Structure
Simcomp
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01683  Thiazolidinedione
 DG02044  Hypoglycemics
  DG01683  Thiazolidinedione
Other
 DG01733  PPAR agonist
  DG01683  Thiazolidinedione
Efficacy
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist
Comment
Thiazolidinedione derivative
Target
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C3 (PPARG)
     D03996  Englitazone sodium (USAN)
Other DBs
CAS: 109229-57-4
PubChem: 47205977
ChEMBL: CHEMBL3989578
LigandBox: D03996
LinkDB
KCF data

ATOM        26
            1   C8x C    29.4000  -21.2800
            2   C8y C    29.4000  -19.8800
            3   C8x C    28.2100  -19.1800
            4   C8y C    26.9500  -19.8800
            5   C8y C    26.9500  -21.2800
            6   C8x C    28.2100  -21.9800
            7   C1x C    25.7600  -19.1800
            8   C1x C    24.5700  -19.8800
            9   C1y C    24.5700  -21.2800
            10  O2x O    25.7600  -21.9800
            11  C1b C    30.5900  -19.1800
            12  C1y C    31.7800  -19.8800
            13  C1b C    23.3100  -21.9800
            14  C8y C    22.1200  -21.2800
            15  C8x C    20.9300  -21.9800
            16  C8x C    19.7400  -21.2800
            17  C8x C    19.7400  -19.8800
            18  C8x C    20.9300  -19.1800
            19  C8x C    22.1200  -19.8800
            20  S2x S    33.1100  -19.3900
            21  C5x C    33.9500  -20.5100
            22  N1x N    33.1800  -21.7000 #-
            23  C5x C    31.7800  -21.2800
            24  O5x O    35.4200  -20.5100
            25  O5x O    30.5900  -21.9800
            26  Z   Na   32.9000  -23.1700 #+
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    2  11 1
            13   11  12 1
            14    9  13 1 #Up
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   14  19 1
            22   12  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   12  23 1
            27   21  24 2
            28   23  25 2

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