KEGG   DRUG: Ephedrine sulfate
Entry
D04018                      Drug                                   

Name
Ephedrine sulfate (USP);
Akovaz (TN);
Corphedra (TN);
Emerphed (TN)
Product
  Generic
Formula
(C10H15NO)2. H2SO4
Exact mass
428.1981
Mol weight
428.5429
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
ATC code: C01CA26 R01AA03 R01AB05 R03CA02 S01FB02
Chemical structure group: DG00227
Product (DG00227): D01386<JP> D04018<US>
Efficacy
Antihypotensive, Bronchodilator, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D04018  Ephedrine sulfate (USP) <US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D04018  Ephedrine sulfate (USP) <US>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D04018  Ephedrine sulfate (USP) <US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D04018  Ephedrine sulfate (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D04018  Ephedrine sulfate (USP) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D04018  Ephedrine sulfate (USP) <US>
    ADRA2
     D04018  Ephedrine sulfate (USP) <US>
    ADRB
     D04018  Ephedrine sulfate (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D04018
Other DBs
CAS: 134-72-5
PubChem: 47205991
ChEMBL: CHEMBL1523964
LigandBox: D04018
NIKKAJI: J244.279E
LinkDB
KCF data

ATOM        29
            1   C8x C     4.7808   -5.6980
            2   C8x C     4.7808   -7.1001
            3   C8x C     5.9980   -7.8012
            4   C8x C     7.2081   -7.1001
            5   C8y C     7.2081   -5.6980
            6   C8x C     5.9980   -4.9969
            7   C1c C     8.4136   -4.9969
            8   C1c C     9.6245   -5.6908
            9   N1b N    10.8354   -4.9898
            10  C1a C    12.0464   -5.6837
            11  O1a O     8.4091   -3.5948
            12  C1a C     9.6275   -7.0930
            13  S4a S    18.7990   -5.6463
            14  O1d O    20.1988   -5.6463
            15  O1d O    17.3991   -5.6861
            16  O1d O    18.8618   -7.0461
            17  O1d O    18.8025   -4.2464
            18  C8x C     4.7808   -5.6980
            19  C8x C     5.9980   -4.9969
            20  C8y C     7.2081   -5.6980
            21  C1c C     8.4136   -4.9969
            22  C1c C     9.6245   -5.6908
            23  N1b N    10.8354   -4.9898
            24  C1a C    12.0464   -5.6837
            25  C1a C     9.6275   -7.0930
            26  O1a O     8.4091   -3.5948
            27  C8x C     7.2081   -7.1001
            28  C8x C     5.9980   -7.8012
            29  C8x C     4.7808   -7.1001
BOND        28
            1    13  14 1
            2    13  15 1
            3    13  16 2
            4    13  17 2
            5     6   1 1
            6     5   7 1
            7     1   2 2
            8     7   8 1
            9     2   3 1
            10    8   9 1
            11    3   4 2
            12    9  10 1
            13    4   5 1
            14    7  11 1 #Up
            15    5   6 2
            16    8  12 1 #Up
            17   19  18 1
            18   20  21 1
            19   18  29 2
            20   21  22 1
            21   29  28 1
            22   22  23 1
            23   28  27 2
            24   23  24 1
            25   27  20 1
            26   21  26 1 #Up
            27   20  19 2
            28   22  25 1 #Up
BRACKET     1     3.9900   -8.6800    3.9900   -2.7300
            1    13.9300   -2.7300   13.9300   -8.6800
            1  2
 ORIGINAL  1    1   6   5   7   8   9  10  12  11   4   3   2
 REPEAT    1   18  19  20  21  22  23  24  25  26  27  28  29

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