| Entry |
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| Name |
Lapatinib ditosylate (USAN);
Lapatinib tosilate hydrate (JAN);
Lapatinib ditosylate monohydrate;
Tykerb (TN);
Tyverb (TN) |
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| Product |
|
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| Generic |
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| Formula |
C29H26ClFN4O4S. (C7H8O3S)2. H2O
|
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| Exact mass |
942.1841
|
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| Mol weight |
943.4761
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| Structure |
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| Class |
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| Remark |
| Therapeutic category: | 4291 |
| Product (DG00715): | D04024<JP/US> |
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| Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
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| Disease |
Breast cancer (HER2 overexpressing) [DS: H00031] |
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| Target |
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| Pathway |
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| Network |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]; CYP2C19 [HSA: 1557], CYP2C8 [HSA: 1558]
Transporter: ABCB1 [HSA: 5243], ABCG2 [HSA: 9429]
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| Interaction |
|
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| Structure map |
| map07045 | Antineoplastics - protein kinase inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EH Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors
L01EH01 Lapatinib
D04024 Lapatinib ditosylate (USAN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Lapatinib
D04024 Lapatinib ditosylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D04024 Lapatinib ditosylate (USAN); Lapatinib tosilate hydrate (JAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG00715 Lapatinib
D04024 Lapatinib ditosylate
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
DG01639 CYP2C19 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
DG02925 CYP3A5 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
Transporter substrate
DG01665 ABCB1 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
DG01913 ABCG2 substrate
DG00715 Lapatinib
D04024 Lapatinib ditosylate
Drug classes [BR:br08332]
Antineoplastic
DG03158 HER2 inhibitor
D04024 Lapatinib ditosylate
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
EGFR family
EGFR
D04024 Lapatinib ditosylate (USAN) <JP/US>
ERBB2* (HER2, CD340) [HSA_VAR:2064v1]
D04024 Lapatinib ditosylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D04024
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D04024
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D04024
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D04024
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04024
Drug transporters
D04024
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
D04024
Polymorphisms and mutations affecting drug response
D04024
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG00715 Lapatinib
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00715 Lapatinib
DG01639 CYP2C19 substrate
DG00715 Lapatinib
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00715 Lapatinib
DG02925 CYP3A5 substrate
DG00715 Lapatinib
Transporter substrate
DG01665 ABCB1 substrate
DG00715 Lapatinib
DG01913 ABCG2 substrate
DG00715 Lapatinib
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 63
1 O0 O 35.3225 -20.0361
2 C8x C 19.9641 -13.5924
3 N5x N 19.9641 -14.9937
4 C8y C 21.1552 -15.6944
5 C8y C 22.4164 -14.9937
6 C8y C 22.4164 -13.5924
7 N5x N 21.1552 -12.8917
8 C8x C 23.6075 -15.6944
9 C8y C 24.7987 -14.9937
10 C8x C 24.7987 -13.5924
11 C8x C 23.6075 -12.8917
12 N1b N 21.1552 -17.0957
13 C8y C 22.3464 -17.7964
14 C8x C 22.3464 -19.1977
15 C8y C 23.6075 -19.8983
16 C8y C 24.7987 -19.1977
17 C8x C 24.7987 -17.7964
18 C8x C 23.6075 -17.0957
19 X Cl 23.6075 -21.2997
20 O2a O 25.9898 -19.8983
21 C1b C 27.1809 -19.1977
22 C8y C 28.3720 -19.8983
23 C8x C 28.3720 -21.2997
24 C8x C 29.6332 -22.0003
25 C8x C 30.8244 -21.2997
26 C8y C 30.8244 -19.8983
27 C8x C 29.6332 -19.1977
28 X F 32.0155 -19.1977
29 C8y C 25.9898 -15.6944
30 C8x C 26.4102 -17.0256
31 C8x C 27.8115 -17.0256
32 C8y C 28.2319 -15.6944
33 O2x O 27.1109 -14.8536
34 C1b C 29.4455 -14.9937
35 N1b N 30.6591 -15.6944
36 C1b C 31.8727 -14.9937
37 C1b C 33.0862 -15.6944
38 S4a S 34.2999 -14.9937
39 C1a C 35.5134 -15.6944
40 O1d O 35.2907 -14.0029
41 O1d O 33.3089 -14.0029
42 C8x C 38.4645 -17.4460
43 C8x C 38.4645 -18.8473
44 C8y C 39.6780 -19.5480
45 C8x C 40.8917 -18.8473
46 C8x C 40.8917 -17.4460
47 C8y C 39.6780 -16.7454
48 C1a C 39.6780 -20.9491
49 S4a S 39.6780 -15.3442
50 O1d O 39.6780 -13.9429
51 O1d O 41.0794 -15.3442
52 O1d O 38.2767 -15.3442
53 C8x C 38.4645 -17.4460
54 C8x C 38.4645 -18.8473
55 C8y C 39.6780 -19.5480
56 C8x C 40.8917 -18.8473
57 C8x C 40.8917 -17.4460
58 C8y C 39.6780 -16.7454
59 S4a S 39.6780 -15.3442
60 O1d O 39.6780 -13.9429
61 O1d O 41.0794 -15.3442
62 O1d O 38.2767 -15.3442
63 C1a C 39.6780 -20.9491
BOND 66
1 2 3 1
2 3 4 2
3 4 5 1
4 5 6 1
5 6 7 1
6 2 7 2
7 5 8 2
8 8 9 1
9 9 10 2
10 10 11 1
11 6 11 2
12 4 12 1
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 16 17 1
18 17 18 2
19 13 18 1
20 15 19 1
21 16 20 1
22 20 21 1
23 21 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 26 27 2
29 22 27 1
30 26 28 1
31 9 29 1
32 30 31 1
33 31 32 2
34 32 33 1
35 33 29 1
36 30 29 2
37 32 34 1
38 34 35 1
39 35 36 1
40 36 37 1
41 37 38 1
42 38 39 1
43 38 40 2
44 38 41 2
45 42 43 2
46 43 44 1
47 44 45 2
48 45 46 1
49 46 47 2
50 42 47 1
51 44 48 1
52 47 49 1
53 49 50 1
54 49 51 2
55 49 52 2
56 53 54 2
57 54 55 1
58 55 56 2
59 56 57 1
60 57 58 2
61 53 58 1
62 55 63 1
63 58 59 1
64 59 60 1
65 59 61 2
66 59 62 2
BRACKET 1 37.6600 -21.8400 37.6600 -13.1600
1 41.9300 -13.1600 41.9300 -21.8400
1 2
ORIGINAL 1 42 43 44 45 46 47 49 50 51 52 48
REPEAT 1 53 54 55 56 57 58 59 60 61 62 63
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