KEGG   DRUG: Etoposide phosphate
Entry
D04107                      Drug                                   

Name
Etoposide phosphate (USAN);
Etopophos (TN)
Product
Formula
C29H33O16P
Exact mass
668.1506
Mol weight
668.5365
Structure
Simcomp
Class
Other
 DG01529  Topoisomerase inhibitor
  DG01527  Topoisomerase II inhibitor
Remark
ATC code: L01CB01
Chemical structure group: DG00693
Product (DG00693): D00125<JP/US> D04107<US>
Efficacy
Antineoplastic, Topoisomerase II inhibitor
  Disease
Testicular tumors [DS:H00023]
Small cell lung cancer [DS:H00013]
Target
TOP2 [HSA:7153 7155] [KO:K03164]
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CB Podophyllotoxin derivatives
     L01CB01 Etoposide
      D04107  Etoposide phosphate (USAN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Enzyme Inhibitors
   Etoposide
    D04107  Etoposide phosphate (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Isomerases (EC5)
   DNA topoisomerase
    TOP2
     D04107  Etoposide phosphate (USAN) <US>
Other DBs
CAS: 117091-64-2
PubChem: 47206058
ChEMBL: CHEMBL1200645 CHEMBL2358914
DrugBank: DB00773
LigandBox: D04107
LinkDB
KCF data

ATOM        46
            1   C8y C    27.7376  -18.0842
            2   C8y C    27.7376  -19.4861
            3   C8x C    28.9516  -20.1870
            4   C8y C    30.1657  -19.4861
            5   C8y C    30.1657  -18.0842
            6   C8x C    28.9516  -17.3833
            7   C1y C    31.3797  -20.1870
            8   C1y C    32.5937  -19.4861
            9   C1y C    32.5937  -18.0842
            10  C1y C    31.3797  -17.3833
            11  O2x O    26.4042  -17.6511
            12  C1x C    25.5803  -18.7851
            13  O2x O    26.4042  -19.9193
            14  C7x C    33.9269  -19.9193
            15  O7x O    34.7510  -18.7851
            16  C1x C    33.9269  -17.6511
            17  O6a O    34.3542  -21.2348
            18  C8y C    31.3797  -21.5888
            19  C8x C    30.1677  -22.2886
            20  C8y C    30.1677  -23.6904
            21  C8y C    31.3817  -24.3914
            22  C8y C    32.5937  -23.6916
            23  C8x C    32.5937  -22.2898
            24  O2a O    28.9706  -24.3818
            25  O2a O    33.7929  -24.3841
            26  C1a C    34.9828  -23.6971
            27  C1a C    27.7827  -23.6960
            28  O2b O    31.3817  -25.7944
            29  O2a O    31.3797  -15.9814
            30  C1y C    30.1677  -15.2817
            31  C1y C    30.1677  -13.8788
            32  C1y C    28.9536  -13.1779
            33  C1y C    27.7396  -13.8788
            34  C1y C    27.7396  -15.2817
            35  O2x O    28.9537  -15.9826
            36  O2x O    26.5255  -13.1779
            37  C1y C    25.3114  -13.8788
            38  O2x O    25.3114  -15.2817
            39  C1x C    26.5255  -15.9826
            40  O1a O    28.9536  -11.7760
            41  C1a C    24.0771  -13.1660
            42  O1a O    31.3990  -13.1677
            43  P1b P    32.5725  -26.4816
            44  O1c O    33.7854  -27.1819
            45  O1c O    33.2751  -25.2645
            46  O1c O    31.8749  -27.6900
BOND        52
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    1  11 1
            13   11  12 1
            14   12  13 1
            15    2  13 1
            16    8  14 1
            17   14  15 1
            18   15  16 1
            19    9  16 1
            20   14  17 2
            21    7  18 1 #Down
            22   18  19 2
            23   19  20 1
            24   20  21 2
            25   21  22 1
            26   22  23 2
            27   18  23 1
            28   20  24 1
            29   22  25 1
            30   25  26 1
            31   24  27 1
            32   21  28 1
            33   10  29 1 #Up
            34   30  29 1 #Down
            35   30  31 1
            36   31  32 1
            37   32  33 1
            38   33  34 1
            39   34  35 1
            40   30  35 1
            41   33  36 1
            42   36  37 1
            43   37  38 1
            44   38  39 1
            45   34  39 1
            46   32  40 1 #Down
            47   37  41 1 #Up
            48   31  42 1 #Up
            49   28  43 1
            50   43  44 1
            51   43  45 2
            52   43  46 1

» Japanese version   » Back

DBGET integrated database retrieval system