KEGG   DRUG: Fluorometholone acetate
Entry
D04221                      Drug                                   

Name
Fluorometholone acetate (USP);
Fluorometholone 17-acetate;
Flarex (TN)
Product
Formula
C24H31FO5
Exact mass
418.2156
Mol weight
418.4983
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C14629
ATC code: C05AA06 D07AB06 D07XB04 D10AA01 S01BA07 S01CB05
Chemical structure group: DG00294
Product (DG00294): D01367<JP/US> D04221<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA06 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB06 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB04 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA01 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA07 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB05 Fluorometholone
      D04221  Fluorometholone acetate (USP) <US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Fluorometholone
     D04221  Fluorometholone acetate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04221  Fluorometholone acetate (USP) <US>
Other DBs
CAS: 3801-06-7
PubChem: 47206167
ChEBI: 78354
ChEMBL: CHEMBL1201064
DrugBank: DB00324
LigandBox: D04221
NIKKAJI: J217.687D
LinkDB
KCF data

ATOM        30
            1   C2x C    16.0712  -19.6831
            2   C5x C    16.0712  -21.0442
            3   C2x C    17.2499  -21.7247
            4   C2y C    18.4285  -21.0442
            5   C1z C    18.4285  -19.6831
            6   C2x C    17.2499  -19.0027
            7   C1y C    19.6072  -21.7247
            8   C1x C    20.7859  -21.0442
            9   C1y C    20.7859  -19.6831
            10  C1z C    19.6072  -19.0027
            11  C1y C    21.9646  -19.0027
            12  C1z C    21.9646  -17.6417
            13  C1x C    20.7859  -16.9612
            14  C1y C    19.6072  -17.6417
            15  C1x C    24.3219  -19.0027
            16  C1x C    24.3219  -17.6417
            17  C1z C    23.1432  -16.9612
            18  X   F    19.6098  -20.3637
            19  C1a C    21.9916  -16.2808
            20  C5a C    23.1484  -15.6002
            21  C1a C    24.3329  -14.9225
            22  C1a C    18.4255  -18.2830
            23  O1a O    18.4055  -16.9479
            24  C1a C    19.6163  -23.1162
            25  O5x O    14.8509  -21.7491
            26  O5a O    21.9253  -14.8873
            27  O7a O    24.3094  -16.2516
            28  C7a C    25.5385  -16.9241
            29  C1a C    26.7454  -16.1893
            30  O6a O    25.5709  -18.3530
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   10  18 1 #Down
            22   12  19 1 #Up
            23   17  20 1 #Up
            24   20  21 1
            25    5  22 1 #Up
            26   14  23 1 #Up
            27    7  24 1 #Down
            28    2  25 2
            29   20  26 2
            30   17  27 1 #Down
            31   27  28 1
            32   28  29 1
            33   28  30 2

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