KEGG   DRUG: Hydrocortisone hemisuccinate
Entry
D04467                      Drug                                   

Name
Hydrocortisone hemisuccinate (USP)
Formula
C25H34O8. H2O
Exact mass
480.2359
Mol weight
480.5479
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D04467  Hydrocortisone hemisuccinate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D04467  Hydrocortisone hemisuccinate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04467
Other DBs
CAS: 83784-20-7
PubChem: 47206324
ChEMBL: CHEMBL3989663
LigandBox: D04467
LinkDB
KCF data

ATOM        34
            1   C1y C    22.3791  -17.5210
            2   C1y C    21.1944  -18.2037
            3   C1z C    22.3791  -16.1553
            4   C1x C    24.7485  -17.5210
            5   C1y C    20.0097  -17.5210
            6   C1x C    21.1827  -19.5753
            7   C1z C    23.5697  -15.4667
            8   C1x C    21.1944  -15.4667
            9   C1a C    22.3733  -14.7838
            10  C1x C    24.7485  -16.1553
            11  C1z C    18.8192  -18.2037
            12  C1y C    20.0097  -16.1553
            13  C1x C    20.0097  -20.2580
            14  C5a C    23.5755  -14.1011
            15  O1a O    24.9120  -15.0932
            16  C2y C    18.8192  -19.5753
            17  C1x C    17.6402  -17.5210
            18  C1a C    18.8075  -16.8381
            19  O1a O    18.8192  -15.4667
            20  C1b C    24.7544  -13.4182
            21  O5a O    22.3850  -13.4182
            22  C2x C    17.6402  -20.2580
            23  C1x C    16.4498  -18.2037
            24  O7a O    25.9449  -14.1068
            25  C5x C    16.4498  -19.5753
            26  O5x O    15.2651  -20.2580
            27  C7a C    27.1456  -13.4077
            28  C1b C    28.3515  -14.0989
            29  C1b C    29.5573  -13.4008
            30  C6a C    30.7632  -14.0918
            31  O6a O    27.1409  -12.0115
            32  O6a O    31.9702  -13.3898
            33  O6a O    30.6972  -15.4695
            34  O0  O    30.5200  -18.2000
BOND        36
            1     3   8 1
            2     3   9 1 #Up
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     6  13 1
            7     7  14 1 #Up
            8     7  15 1 #Down
            9    11  16 1
            10   11  17 1
            11   11  18 1 #Up
            12   12  19 1 #Up
            13   14  20 1
            14   14  21 2
            15   16  22 2
            16   17  23 1
            17   20  24 1
            18   22  25 1
            19   25  26 2
            20    7  10 1
            21    8  12 1
            22   13  16 1
            23   23  25 1
            24   24  27 1
            25    1   2 1
            26   27  28 1
            27    1   3 1
            28   28  29 1
            29    1   4 1
            30   29  30 1
            31    2   5 1
            32   27  31 2
            33    2   6 1
            34    3   7 1
            35   30  32 1
            36   30  33 2

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