KEGG   DRUG: Lenalidomide
Entry
D04687                      Drug                                   

Name
Lenalidomide (USAN/INN);
Revlimid (TN)
Product
Formula
C13H13N3O3
Exact mass
259.0957
Mol weight
259.2606
Structure
Simcomp
Class
Other
 DG01936  TNF inhibitor
Remark
ATC code: L04AX04
Chemical structure group: DG00744
Product (DG00744): D04687<US> D09813<JP>
Efficacy
Antineoplastic, Immunomodulator, TNF-alpha inhibitor
  Disease
Multiple myeloma [DS:H00010]
Myelodysplastic syndromes (chromosome 5q deletion) [DS:H01484]
Mantle cell lymphoma [DS:H01464]
Follicular lymphoma [DS:H01613]
Comment
Thalidomide [DR:D00754] derivative
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04640  Hematopoietic cell lineage
hsa04650  Natural killer cell mediated cytotoxicity
hsa04668  TNF signaling pathway
Interaction
Structure map
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX04 Lenalidomide
      D04687  Lenalidomide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antiangiogenic Agents
   Lenalidomide
    D04687  Lenalidomide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D04687  Lenalidomide (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04687
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04687
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04687
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D04687
Other DBs
CAS: 191732-72-6
PubChem: 47206522
ChEBI: 63791
ChEMBL: CHEMBL848
DrugBank: DB00480
LigandBox: D04687
NIKKAJI: J1.121.689G
LinkDB
KCF data

ATOM        19
            1   C8x C    12.8800  -15.7500
            2   C8x C    12.8800  -17.1500
            3   C8x C    14.0924  -17.8500
            4   C8y C    15.3049  -17.1500
            5   C8y C    15.3049  -15.7500
            6   C8y C    14.0924  -15.0500
            7   C5x C    16.6364  -17.5826
            8   N1y N    17.4593  -16.4500
            9   C1x C    16.6364  -15.3174
            10  C1y C    18.8300  -16.4500
            11  O5x O    17.0675  -18.9094
            12  N1a N    14.0924  -13.6502
            13  C1x C    19.5300  -17.6624
            14  C1x C    20.9300  -17.6624
            15  C5x C    21.6300  -16.4500
            16  N1x N    20.9300  -15.2376
            17  C5x C    19.5300  -15.2376
            18  O5x O    18.8396  -14.0421
            19  O5x O    23.0300  -16.4500
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    7  11 2
            13    6  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   10  17 1
            20   17  18 2
            21   15  19 2

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