KEGG   DRUG: Levoleucovorin calcium
Entry
D04715                      Drug                                   

Name
Levoleucovorin calcium (USAN);
Calcium levofolinate (INN);
Levofolinate calcium (JAN);
Fusilev (TN);
Isovorin (TN)
Product
  Generic
Formula
C20H21N7O7. Ca
Exact mass
511.1128
Mol weight
511.5014
Structure
Simcomp
Remark
Therapeutic category: 3929
ATC code: V03AF04
Chemical structure group: DG03003
Product (DG03003): D04715<JP/US> D11394<US> D11555<US>
Efficacy
Antidote (antifolate), Antineoplastic (enhancer)
  Disease
Osteosarcoma [DS:H00036]
Colorectal cancer [DS:H00020]
Comment
Tetrahydrofolic acid [CPD:C00101] derivative
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF04 Calcium levofolinate
      D04715  Levoleucovorin calcium (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Treatment Adjuncts
   Levoleucovorin
    D04715  Levoleucovorin calcium (USAN)
  Antineoplastics, Other
   Levoleucovorin
    D04715  Levoleucovorin calcium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   392  Antidotes
    3929  Others
     D04715  Levoleucovorin calcium (USAN); Calcium levofolinate (INN); Levofolinate calcium (JAN)
Other DBs
CAS: 80433-71-2
PubChem: 47206540
ChEMBL: CHEMBL1201138 CHEMBL1908361
LigandBox: D04715
NIKKAJI: J523.873K
LinkDB
KCF data

ATOM        35
            1   C1c C    24.1500  -14.7700
            2   C1b C    25.3400  -15.4700
            3   C6a C    24.1500  -13.3700
            4   C8y C     9.6600  -18.9700
            5   N5x N     9.6600  -17.5700
            6   C8y C    10.8500  -16.8700
            7   C8y C    12.0400  -17.5700
            8   C8y C    12.0400  -18.9700
            9   N4x N    10.8500  -19.6700
            10  N1y N    13.3000  -16.8700
            11  C1y C    14.4900  -17.5700
            12  C1x C    14.4900  -18.9700
            13  N1x N    13.3000  -19.6700
            14  O5x O    10.8500  -15.4700
            15  C4a C    13.3000  -15.4700
            16  O4a O    14.4900  -14.7700
            17  N1a N     8.4000  -19.6700
            18  C1b C    15.6800  -16.8700
            19  N1b N    16.8700  -17.5700
            20  C8y C    18.0600  -16.8700
            21  C8x C    18.0600  -15.4700
            22  C8x C    19.3200  -14.7700
            23  C8y C    20.5100  -15.4700
            24  C8x C    20.5100  -16.8700
            25  C8x C    19.3200  -17.5700
            26  C5a C    21.7700  -14.7700
            27  N1b N    22.9600  -15.4700
            28  O5a O    21.7700  -13.3700
            29  O6a O    25.3400  -12.6700 #-
            30  O6a O    22.8900  -12.6700
            31  C1b C    26.5300  -14.7700
            32  C6a C    27.7200  -15.4700
            33  O6a O    28.9100  -14.7700 #-
            34  O6a O    27.7200  -16.8700
            35  Z   Ca   28.0700  -12.6700 #2+
BOND        36
            1     1   2 1
            2     1   3 1 #Down
            3     4   5 2
            4     5   6 1
            5     6   7 1
            6     7   8 2
            7     8   9 1
            8     4   9 1
            9     7  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    8  13 1
            14    6  14 2
            15   10  15 1
            16   15  16 2
            17    4  17 1
            18   11  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   20  25 1
            27   23  26 1
            28   26  27 1
            29   26  28 2
            30    1  27 1
            31    3  29 1
            32    3  30 2
            33    2  31 1
            34   31  32 1
            35   32  33 1
            36   32  34 2

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