KEGG   DRUG: Framycetin
Entry
D05140                      Drug                                   

Name
Framycetin (INN);
Fradiomycin B;
Neomycin B;
FRM
Formula
C23H46N6O13
Exact mass
614.3123
Mol weight
614.6437
Structure
Simcomp
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Same as: C01737
ATC code: D09AA01 R01AX08 S01AA07
Chemical structure group: DG01446
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA01 Framycetin
      D05140  Framycetin (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX08 Framycetin
      D05140  Framycetin (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA07 Framycetin
      D05140  Framycetin (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Fradiomycin
    D05140  Framycetin (INN)
Other DBs
CAS: 119-04-0
PubChem: 17398248
ChEBI: 7508
ChEMBL: CHEMBL184618
DrugBank: DB00452
PDB-CCD: NMY[PDBj]
LigandBox: D05140
NIKKAJI: J4.458J
LinkDB
KCF data

ATOM        42
            1   C1y C    18.5833  -19.8269
            2   C1y C    18.5833  -21.2133
            3   C1y C    19.8310  -21.9065
            4   C1y C    21.0095  -21.2133
            5   C1y C    21.0095  -19.8269
            6   O2x O    19.8310  -19.1338
            7   O2a O    22.1879  -19.1338
            8   C1y C    24.4062  -17.9554
            9   C1y C    24.8221  -16.6383
            10  O2x O    23.7129  -15.8758
            11  C1y C    22.6038  -16.6383
            12  C1y C    23.0198  -17.9554
            13  O2a O    26.4855  -16.2224
            14  O1a O    26.9013  -18.9951
            15  C1y C    28.0797  -18.3019
            16  C1y C    29.2581  -18.9951
            17  C1x C    30.4365  -18.3019
            18  C1y C    30.4365  -16.9155
            19  C1y C    29.2581  -16.2224
            20  C1y C    28.0797  -16.9155
            21  N1a N    29.2581  -20.3815
            22  N1a N    31.6149  -16.2224
            23  O2a O    29.2581  -14.8360
            24  C1y C    30.4365  -14.1428
            25  O2x O    31.6149  -14.8360
            26  C1y C    32.7934  -14.1428
            27  C1y C    32.7934  -12.7564
            28  C1y C    31.6149  -12.0632
            29  C1y C    30.4365  -12.7564
            30  C1b C    34.0411  -14.7666
            31  N1a N    34.0411  -16.1530
            32  N1a N    29.1887  -12.0632
            33  O1a O    31.6149  -10.6768
            34  O1a O    34.0411  -11.9939
            35  C1b C    21.2868  -16.2224
            36  O1a O    25.2380  -19.1338
            37  O1a O    20.2469  -17.1928
            38  C1b C    17.4049  -19.1338
            39  O1a O    17.4049  -21.9065
            40  N1a N    22.1879  -21.9065
            41  O1a O    19.8310  -23.2929
            42  N1a N    16.1987  -19.8171
BOND        45
            1    25  26 1
            2    26  27 1
            3    27  28 1
            4    28  29 1
            5    29  24 1
            6    26  30 1 #Up
            7    15  14 1 #Down
            8    30  31 1
            9     5   7 1 #Down
            10   29  32 1 #Down
            11   28  33 1 #Up
            12    1   2 1
            13   27  34 1 #Down
            14    2   3 1
            15   11  35 1 #Up
            16   12   7 1 #Down
            17    3   4 1
            18    8  36 1 #Down
            19   15  16 1
            20   35  37 1
            21   16  17 1
            22    1  38 1 #Down
            23   17  18 1
            24    2  39 1 #Down
            25   18  19 1
            26    4  40 1 #Down
            27   19  20 1
            28    3  41 1 #Up
            29   20  15 1
            30    4   5 1
            31   16  21 1 #Up
            32    8   9 1
            33   18  22 1 #Up
            34    9  10 1
            35   19  23 1 #Down
            36   20  13 1 #Up
            37   10  11 1
            38   24  23 1 #Down
            39   11  12 1
            40   12   8 1
            41    5   6 1
            42    9  13 1 #Up
            43    6   1 1
            44   24  25 1
            45   38  42 1

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