KEGG   DRUG: Norepinephrine bitartrate
Entry
D05206                      Drug                                   
Name
Norepinephrine bitartrate (USP);
Levophed (TN)
Product
LEVOPHED (Hospira), LEVOPHED (Hospira), LEVOPHED(R) NOREPINEPHRINE BITARTRATE (HF Acquisition Co LLC), NOREPINEPHRINE (Long Grove Pharmaceuticals), NOREPINEPHRINE BITARTRATE (Baxter Healthcare Corporation), NOREPINEPHRINE BITARTRATE IN SODIUM CHLORIDE (WG Critical Care)
  Generic
NOREPINEPHR BITART (Delpharm Boucherville Canada), NOREPINEPHRINE BITARTRATE (Amneal Pharmaceuticals LLC), NOREPINEPHRINE BITARTRATE (BE Pharmaceuticals), NOREPINEPHRINE BITARTRATE (Baxter Healthcare Corporation), NOREPINEPHRINE BITARTRATE (Baxter Healthcare Corporation), NOREPINEPHRINE BITARTRATE (Breckenridge Pharmaceutical), NOREPINEPHRINE BITARTRATE (Caplin Steriles Limited), NOREPINEPHRINE BITARTRATE (Civica), NOREPINEPHRINE BITARTRATE (Fresenius Kabi USA), NOREPINEPHRINE BITARTRATE (Fresenius Kabi USA), NOREPINEPHRINE BITARTRATE (Gland Pharma Limited), NOREPINEPHRINE BITARTRATE (HF Acquisition Co LLC), NOREPINEPHRINE BITARTRATE (Hikma Pharmaceuticals USA), NOREPINEPHRINE BITARTRATE (Mylan Institutional LLC), NOREPINEPHRINE BITARTRATE (Mylan Institutional LLC), NOREPINEPHRINE BITARTRATE (NorthStar Rx LLC), NOREPINEPHRINE BITARTRATE (Sagent Pharmaceuticals), NOREPINEPHRINE BITARTRATE (Sandoz), NOREPINEPHRINE BITARTRATE (Sun Pharmaceutical Industries)
Formula
C8H11NO3. C4H6O6. H2O
Exact mass
337.1009
Mol weight
337.28
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
  Disease
Myocardial infarction [DS:H01730]
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D05206  Norepinephrine bitartrate (USP) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00212  Norepinephrine
     D05206  Norepinephrine bitartrate
  DG01456  Adrenergic receptor agonist
   DG00212  Norepinephrine
    D05206  Norepinephrine bitartrate
  DG01951  Catecholamine adrenergic receptor agonist
   DG00212  Norepinephrine
    D05206  Norepinephrine bitartrate
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00212  Norepinephrine
    D05206  Norepinephrine bitartrate
  DG02917  MAO substrate
   DG00212  Norepinephrine
    D05206  Norepinephrine bitartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRA2
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRB
     D05206  Norepinephrine bitartrate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05206
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00212  Norepinephrine
  DG01456  Adrenergic receptor agonist
   DG00212  Norepinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00212  Norepinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00212  Norepinephrine
  DG02917  MAO substrate
   DG00212  Norepinephrine
Other DBs
CAS: 69815-49-2
PubChem: 47206925
LigandBox: D05206
LinkDB
KCF data

ATOM        23
            1   C8y C    35.0700  -25.6900
            2   C8x C    35.0700  -27.0900
            3   C8x C    33.8100  -24.9900
            4   C1c C    36.2600  -24.9900
            5   C8x C    33.8100  -27.7900
            6   C8y C    32.6200  -25.6900
            7   C1b C    37.4500  -25.6900
            8   O1a O    36.2600  -23.5900
            9   C8y C    32.6200  -27.0900
            10  N1a N    38.6400  -24.9900
            11  O1a O    31.4300  -27.7900
            12  O1a O    31.4300  -24.9900
            13  O6a O    41.7200  -26.1100
            14  C6a C    42.9800  -25.4100
            15  C1c C    44.1700  -26.1100
            16  C1c C    45.3600  -25.4100
            17  C6a C    46.6200  -26.1100
            18  O6a O    47.8100  -25.4100
            19  O6a O    42.9800  -24.0100
            20  O1a O    44.1700  -27.5100
            21  O1a O    45.3600  -24.0100
            22  O6a O    46.6200  -27.5100
            23  O0  O    51.8700  -26.3200
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   14  19 2
            19   15  20 1 #Up
            20   16  21 1 #Up
            21   17  22 2

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