KEGG   DRUG: Norepinephrine bitartrate
Entry
D05206                      Drug                                   

Name
Norepinephrine bitartrate (USP);
Levophed (TN)
Product
  Generic
Formula
C8H11NO3. C4H6O6. H2O
Exact mass
337.1009
Mol weight
337.28
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Remark
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
  Disease
Myocardial infarction [DS:H01730]
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D05206  Norepinephrine bitartrate (USP) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRA2
     D05206  Norepinephrine bitartrate (USP) <US>
    ADRB
     D05206  Norepinephrine bitartrate (USP) <US>
Other DBs
CAS: 69815-49-2
PubChem: 47206925
DrugBank: DB00368
LigandBox: D05206
LinkDB
KCF data

ATOM        23
            1   C8y C    35.0700  -25.6900
            2   C8x C    35.0700  -27.0900
            3   C8x C    33.8100  -24.9900
            4   C1c C    36.2600  -24.9900
            5   C8x C    33.8100  -27.7900
            6   C8y C    32.6200  -25.6900
            7   C1b C    37.4500  -25.6900
            8   O1a O    36.2600  -23.5900
            9   C8y C    32.6200  -27.0900
            10  N1a N    38.6400  -24.9900
            11  O1a O    31.4300  -27.7900
            12  O1a O    31.4300  -24.9900
            13  O6a O    41.7200  -26.1100
            14  C6a C    42.9800  -25.4100
            15  C1c C    44.1700  -26.1100
            16  C1c C    45.3600  -25.4100
            17  C6a C    46.6200  -26.1100
            18  O6a O    47.8100  -25.4100
            19  O6a O    42.9800  -24.0100
            20  O1a O    44.1700  -27.5100
            21  O1a O    45.3600  -24.0100
            22  O6a O    46.6200  -27.5100
            23  O0  O    51.8700  -26.3200
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   14  19 2
            19   15  20 1 #Up
            20   16  21 1 #Up
            21   17  22 2

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