KEGG   DRUG: Phentermine hydrochloride
Entry
D05459                      Drug                                   

Name
Phentermine hydrochloride (USP);
Adipex-p (TN);
Fastin (TN)
Product
  Generic
ADIPEX-P (Advanced Rx Pharmacy of Tennessee), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (A-S Medication Solutions), PHENTERMINE HYDROCHLORIDE (Apotheca), PHENTERMINE HYDROCHLORIDE (Apotheca), PHENTERMINE HYDROCHLORIDE (Asclemed USA), PHENTERMINE HYDROCHLORIDE (Asclemed USA), PHENTERMINE HYDROCHLORIDE (Aurolife Pharma), PHENTERMINE (Aurolife Pharma), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), LOMAIRA (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (Bryant Ranch Prepack), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (CALVIN), PHENTERMINE HYDROCHLORIDE (Cadila Healthcare Limited), PHENTERMINE HYDROCHLORIDE (DIRECT RX), PHENTERMINE HYDROCHLORIDE (Denton Pharma), PHENTERMINE HYDROCHLORIDE (Direct_Rx), PHENTERMINE HYDROCHLORIDE (Direct_Rx), PHENTERMINE HYDROCHLORIDE (Elite Laboratories), PHENTERMINE HYDROCHLORIDE (Eon Labs), PHENTERMINE HYDROCHLORIDE (Epic Pharma), PHENTERMINE HYDROCHLORIDE (Epic Pharma), LOMAIRA (KVK-TECH), PHENTERMINE HYDROCHLORIDE (KVK-TECH), PHENTERMINE HYDROCHLORIDE (KVK-TECH), PHENTERMINE HYDROCHLORIDE (KVK-Tech), PHENTERMINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products), PHENTERMINE HYDROCHLORIDE (Lannett Company), PHENTERMINE HYDROCHLORIDE (Lannett Company), PHENTERMINE HYDROCHLORIDE (Lannett Company), PHENTERMINE HYDROCHLORIDE (NuCare Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (NuCare Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (NuCare Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (NuCare Pharmaceuticals), ADIPEX-P (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (POLYGEN PHARMACEUTICALS), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Preferred Pharmaceuticals), PHENTERMINE (Preferred Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (Proficient Rx LP), PHENTERMINE HYDROCHLORIDE (REMEDYREPACK), PHENTERMINE HYDROCHLORIDE (Rising Pharmaceuticals), PHENTERMINE HYDROCHLORIDE (SUNRISE PHARMACEUTICAL), PHENTERMINE HYDROCHLORIDE (SUNRISE PHARMACEUTICAL), PHENTERMINE HYDROCHLORIDE (Solco Healthcare U.S.), PHENTERMINE HYDROCHLORIDE (Sun Pharmaceutical Industries), PHENTERMINE HYDROCHLORIDE (TAGI Pharma), PHENTERMINE HYDROCHLORIDE (TAGI Pharma), ADIPEX-P (Teva Pharmaceuticals USA), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Unit Dose Services), PHENTERMINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), PHENTERMINE HYDROCHLORIDE (direct rx), PHENTERMINE HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C10H15N. HCl
Exact mass
185.0971
Mol weight
185.6937
Structure
Simcomp
Class
Other
 DG01706  Antiobesity
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
Remark
ATC code: A08AA01
Chemical structure group: DG00102
Product (DG00102): D05459<US>
Product (mixture): D11710<US>
Efficacy
Appetite suppressant (systemic)
Comment
Amphetamine [DR:D07445] analog
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
MAO [HSA:4128 4129] [KO:K00274]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA01 Phentermine
      D05459  Phentermine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Anti-Obesity Agents
  Phentermine
   D05459  Phentermine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D05459  Phentermine hydrochloride (USP) <US>
    SLC6A3 (DAT1)
     D05459  Phentermine hydrochloride (USP) <US>
    SLC6A4 (HTT)
     D05459  Phentermine hydrochloride (USP) <US>
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAO
     D05459  Phentermine hydrochloride (USP) <US>
Other DBs
CAS: 1197-21-3
PubChem: 47207128
ChEBI: 50506
ChEMBL: CHEMBL1200912
DrugBank: DB00191
LigandBox: D05459
NIKKAJI: J349.683J
LinkDB
KCF data

ATOM        12
            1   C8y C    16.8000  -15.8900
            2   C1b C    17.9900  -15.1900
            3   C8x C    16.8000  -17.2900
            4   C8x C    15.6100  -15.1900
            5   C1d C    19.1800  -15.8900
            6   C8x C    15.6100  -17.9900
            7   C8x C    14.4200  -15.8900
            8   C1a C    19.1800  -14.3500
            9   C1a C    19.1800  -17.2900
            10  N1a N    20.3700  -15.1900
            11  C8x C    14.4200  -17.2900
            12  X   Cl   22.8900  -16.5900
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 1
            9     5  10 1
            10    6  11 2
            11    7  11 1

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