KEGG   DRUG: Piroxicam betadex
Entry
D05511                      Drug                                   

Name
Piroxicam betadex (USAN)
Formula
(C42H70O35)5. (C15H13N3O4S)2
Exact mass
6333.9742
Mol weight
6337.6138
Structure
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
 DG01910  Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: M01AC01 M02AA07 S01BC06
Chemical structure group: DG00752
Product (DG00752): D00127<JP/US>
Efficacy
Analgesic, Anti-inflammatory, Antirheumatic, COX inhibitor
Comment
Oxicams
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC01 Piroxicam
      D05511  Piroxicam betadex (USAN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA07 Piroxicam
      D05511  Piroxicam betadex (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC06 Piroxicam
      D05511  Piroxicam betadex (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D05511  Piroxicam betadex (USAN)
    PTGS2 (COX2)
     D05511  Piroxicam betadex (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05511
Other DBs
CAS: 96684-40-1
PubChem: 47207180
DrugBank: DB00554
LigandBox: D05511
LinkDB
KCF data

ATOM        431
            1   C1y C    42.5984  -21.6427
            2   C1y C    41.2126  -21.6427
            3   O2x O    40.5309  -22.8232
            4   C1y C    41.2125  -24.0738
            5   C1y C    42.5983  -24.0040
            6   C1y C    43.2799  -22.8233
            7   C1y C    30.4187  -21.6430
            8   C1y C    29.7279  -22.8374
            9   C1y C    30.4089  -24.0185
            10  C1y C    31.7722  -24.0194
            11  C1y C    32.4628  -22.8249
            12  O2x O    31.7819  -21.6439
            13  C1y C    41.2326  -16.9043
            14  C1y C    40.5511  -18.0850
            15  O2x O    41.2326  -19.2657
            16  C1y C    42.5960  -19.2657
            17  C1y C    43.2776  -18.0850
            18  C1y C    42.5960  -16.9043
            19  C1y C    31.7834  -16.9043
            20  C1y C    30.4201  -16.9043
            21  C1y C    29.7384  -18.0850
            22  C1y C    30.4201  -19.2657
            23  C1y C    31.7834  -19.2657
            24  O2x O    32.4651  -18.0850
            25  C1y C    32.9641  -13.4962
            26  C1y C    32.9641  -14.8595
            27  C1y C    34.1447  -15.5412
            28  O2x O    35.3255  -14.8595
            29  C1y C    35.3255  -13.4962
            30  C1y C    34.1447  -12.8145
            31  C1b C    36.5061  -15.5412
            32  C1y C    37.6867  -14.8595
            33  C1y C    37.6867  -13.4962
            34  O2a O    36.5061  -12.8145
            35  O2x O    38.8674  -15.5412
            36  C1y C    40.0481  -14.8595
            37  C1y C    40.0481  -13.4962
            38  C1y C    38.8674  -12.8145
            39  O1a O    31.7835  -12.8145
            40  O1a O    38.8674  -11.4516
            41  O1a O    34.1447  -11.4515
            42  O2a O    31.7835  -15.5412
            43  O1a O    41.2326  -12.8123
            44  O2a O    41.2326  -15.5434
            45  O1a O    36.5061  -16.9044
            46  O1a O    44.6202  -18.0846
            47  O2a O    43.2832  -20.4554
            48  O1a O    29.7442  -15.7334
            49  O2a O    29.7332  -20.4548
            50  O1a O    28.3972  -18.0846
            51  C1b C    32.4811  -20.4743
            52  C1b C    34.1447  -17.3184
            53  C1b C    39.1674  -18.0853
            54  O1a O    43.2722  -15.7328
            55  O1a O    35.3090  -17.9907
            56  O1a O    38.4955  -19.2496
            57  O1a O    33.8501  -20.4746
            58  O1a O    28.3970  -22.8365
            59  O2a O    32.4501  -25.1949
            60  O2a O    40.5352  -25.1771
            61  O1a O    43.2695  -25.1671
            62  C1b C    33.8503  -22.8256
            63  O1a O    29.7459  -25.1659
            64  C1b C    40.5451  -20.4871
            65  O1a O    44.6204  -22.8235
            66  O1a O    39.1675  -20.4872
            67  O1a O    34.5286  -21.6523
            68  C1y C    35.7902  -25.1949
            69  O2x O    36.4750  -26.3807
            70  C1y C    37.8384  -26.3805
            71  C1y C    38.5198  -25.1998
            72  C1y C    37.8350  -24.0140
            73  C1y C    36.4716  -24.0141
            74  O1a O    38.5172  -22.8319
            75  C1b C    38.5276  -27.5749
            76  O1a O    35.7736  -22.8047
            77  O1a O    39.9166  -27.5744
            78  C8y C    15.3404  -19.4275
            79  C8y C    15.3404  -20.8045
            80  C8y C    16.5296  -18.7265
            81  C8x C    14.1450  -18.7454
            82  S2x S    16.5421  -21.4930
            83  C8x C    14.1450  -21.4992
            84  C8y C    17.7313  -19.4213
            85  O1a O    16.5234  -17.3684
            86  C8x C    12.9684  -19.4275
            87  N4y N    17.6738  -20.8107
            88  O3c O    14.9899  -22.4631
            89  O3c O    17.9315  -22.4130
            90  C8x C    12.9684  -20.8045
            91  C5a C    18.9077  -18.7329
            92  C1a C    18.9203  -21.4866
            93  O5a O    18.9016  -17.3747
            94  N1b N    20.0916  -19.4083
            95  C8y C    21.2687  -18.7205
            96  N5x N    22.4462  -19.3925
            97  C8x C    23.6231  -18.7047
            98  C8x C    23.6160  -17.3417
            99  C8x C    22.4321  -16.6661
            100 C8x C    21.2553  -17.3539
            101 C1y C    42.5984  -21.6427
            102 C1y C    41.2126  -21.6427
            103 O2x O    40.5309  -22.8232
            104 C1y C    41.2125  -24.0738
            105 C1y C    42.5983  -24.0040
            106 C1y C    43.2799  -22.8233
            107 O1a O    44.6204  -22.8235
            108 O1a O    43.2695  -25.1671
            109 O2a O    40.5352  -25.1771
            110 C1y C    38.5198  -25.1998
            111 C1y C    37.8384  -26.3805
            112 O2x O    36.4750  -26.3807
            113 C1y C    35.7902  -25.1949
            114 C1y C    36.4716  -24.0141
            115 C1y C    37.8350  -24.0140
            116 O1a O    38.5172  -22.8319
            117 O1a O    35.7736  -22.8047
            118 O2a O    32.4501  -25.1949
            119 C1y C    31.7722  -24.0194
            120 C1y C    30.4089  -24.0185
            121 C1y C    29.7279  -22.8374
            122 C1y C    30.4187  -21.6430
            123 O2x O    31.7819  -21.6439
            124 C1y C    32.4628  -22.8249
            125 C1b C    33.8503  -22.8256
            126 O1a O    34.5286  -21.6523
            127 O2a O    29.7332  -20.4548
            128 C1y C    30.4201  -19.2657
            129 C1y C    29.7384  -18.0850
            130 C1y C    30.4201  -16.9043
            131 C1y C    31.7834  -16.9043
            132 O2x O    32.4651  -18.0850
            133 C1y C    31.7834  -19.2657
            134 C1b C    32.4811  -20.4743
            135 O1a O    33.8501  -20.4746
            136 O2a O    31.7835  -15.5412
            137 C1y C    32.9641  -14.8595
            138 C1y C    32.9641  -13.4962
            139 C1y C    34.1447  -12.8145
            140 C1y C    35.3255  -13.4962
            141 O2x O    35.3255  -14.8595
            142 C1y C    34.1447  -15.5412
            143 C1b C    34.1447  -17.3184
            144 O1a O    35.3090  -17.9907
            145 O2a O    36.5061  -12.8145
            146 C1y C    37.6867  -13.4962
            147 C1y C    37.6867  -14.8595
            148 C1b C    36.5061  -15.5412
            149 O1a O    36.5061  -16.9044
            150 O2x O    38.8674  -15.5412
            151 C1y C    40.0481  -14.8595
            152 C1y C    40.0481  -13.4962
            153 C1y C    38.8674  -12.8145
            154 O1a O    38.8674  -11.4516
            155 O1a O    41.2326  -12.8123
            156 O2a O    41.2326  -15.5434
            157 C1y C    41.2326  -16.9043
            158 C1y C    40.5511  -18.0850
            159 O2x O    41.2326  -19.2657
            160 C1y C    42.5960  -19.2657
            161 C1y C    43.2776  -18.0850
            162 C1y C    42.5960  -16.9043
            163 O1a O    43.2722  -15.7328
            164 O1a O    44.6202  -18.0846
            165 O2a O    43.2832  -20.4554
            166 C1b C    39.1674  -18.0853
            167 O1a O    38.4955  -19.2496
            168 O1a O    34.1447  -11.4515
            169 O1a O    31.7835  -12.8145
            170 O1a O    29.7442  -15.7334
            171 O1a O    28.3972  -18.0846
            172 O1a O    28.3970  -22.8365
            173 O1a O    29.7459  -25.1659
            174 C1b C    38.5276  -27.5749
            175 O1a O    39.9166  -27.5744
            176 C1b C    40.5451  -20.4871
            177 O1a O    39.1675  -20.4872
            178 C1y C    42.5984  -21.6427
            179 C1y C    41.2126  -21.6427
            180 O2x O    40.5309  -22.8232
            181 C1y C    41.2125  -24.0738
            182 C1y C    42.5983  -24.0040
            183 C1y C    43.2799  -22.8233
            184 O1a O    44.6204  -22.8235
            185 O1a O    43.2695  -25.1671
            186 O2a O    40.5352  -25.1771
            187 C1y C    38.5198  -25.1998
            188 C1y C    37.8384  -26.3805
            189 O2x O    36.4750  -26.3807
            190 C1y C    35.7902  -25.1949
            191 C1y C    36.4716  -24.0141
            192 C1y C    37.8350  -24.0140
            193 O1a O    38.5172  -22.8319
            194 O1a O    35.7736  -22.8047
            195 O2a O    32.4501  -25.1949
            196 C1y C    31.7722  -24.0194
            197 C1y C    30.4089  -24.0185
            198 C1y C    29.7279  -22.8374
            199 C1y C    30.4187  -21.6430
            200 O2x O    31.7819  -21.6439
            201 C1y C    32.4628  -22.8249
            202 C1b C    33.8503  -22.8256
            203 O1a O    34.5286  -21.6523
            204 O2a O    29.7332  -20.4548
            205 C1y C    30.4201  -19.2657
            206 C1y C    29.7384  -18.0850
            207 C1y C    30.4201  -16.9043
            208 C1y C    31.7834  -16.9043
            209 O2x O    32.4651  -18.0850
            210 C1y C    31.7834  -19.2657
            211 C1b C    32.4811  -20.4743
            212 O1a O    33.8501  -20.4746
            213 O2a O    31.7835  -15.5412
            214 C1y C    32.9641  -14.8595
            215 C1y C    32.9641  -13.4962
            216 C1y C    34.1447  -12.8145
            217 C1y C    35.3255  -13.4962
            218 O2x O    35.3255  -14.8595
            219 C1y C    34.1447  -15.5412
            220 C1b C    34.1447  -17.3184
            221 O1a O    35.3090  -17.9907
            222 O2a O    36.5061  -12.8145
            223 C1y C    37.6867  -13.4962
            224 C1y C    37.6867  -14.8595
            225 C1b C    36.5061  -15.5412
            226 O1a O    36.5061  -16.9044
            227 O2x O    38.8674  -15.5412
            228 C1y C    40.0481  -14.8595
            229 C1y C    40.0481  -13.4962
            230 C1y C    38.8674  -12.8145
            231 O1a O    38.8674  -11.4516
            232 O1a O    41.2326  -12.8123
            233 O2a O    41.2326  -15.5434
            234 C1y C    41.2326  -16.9043
            235 C1y C    40.5511  -18.0850
            236 O2x O    41.2326  -19.2657
            237 C1y C    42.5960  -19.2657
            238 C1y C    43.2776  -18.0850
            239 C1y C    42.5960  -16.9043
            240 O1a O    43.2722  -15.7328
            241 O1a O    44.6202  -18.0846
            242 O2a O    43.2832  -20.4554
            243 C1b C    39.1674  -18.0853
            244 O1a O    38.4955  -19.2496
            245 O1a O    34.1447  -11.4515
            246 O1a O    31.7835  -12.8145
            247 O1a O    29.7442  -15.7334
            248 O1a O    28.3972  -18.0846
            249 O1a O    28.3970  -22.8365
            250 O1a O    29.7459  -25.1659
            251 C1b C    38.5276  -27.5749
            252 O1a O    39.9166  -27.5744
            253 C1b C    40.5451  -20.4871
            254 O1a O    39.1675  -20.4872
            255 C1y C    42.5984  -21.6427
            256 C1y C    41.2126  -21.6427
            257 O2x O    40.5309  -22.8232
            258 C1y C    41.2125  -24.0738
            259 C1y C    42.5983  -24.0040
            260 C1y C    43.2799  -22.8233
            261 O1a O    44.6204  -22.8235
            262 O1a O    43.2695  -25.1671
            263 O2a O    40.5352  -25.1771
            264 C1y C    38.5198  -25.1998
            265 C1y C    37.8384  -26.3805
            266 O2x O    36.4750  -26.3807
            267 C1y C    35.7902  -25.1949
            268 C1y C    36.4716  -24.0141
            269 C1y C    37.8350  -24.0140
            270 O1a O    38.5172  -22.8319
            271 O1a O    35.7736  -22.8047
            272 O2a O    32.4501  -25.1949
            273 C1y C    31.7722  -24.0194
            274 C1y C    30.4089  -24.0185
            275 C1y C    29.7279  -22.8374
            276 C1y C    30.4187  -21.6430
            277 O2x O    31.7819  -21.6439
            278 C1y C    32.4628  -22.8249
            279 C1b C    33.8503  -22.8256
            280 O1a O    34.5286  -21.6523
            281 O2a O    29.7332  -20.4548
            282 C1y C    30.4201  -19.2657
            283 C1y C    29.7384  -18.0850
            284 C1y C    30.4201  -16.9043
            285 C1y C    31.7834  -16.9043
            286 O2x O    32.4651  -18.0850
            287 C1y C    31.7834  -19.2657
            288 C1b C    32.4811  -20.4743
            289 O1a O    33.8501  -20.4746
            290 O2a O    31.7835  -15.5412
            291 C1y C    32.9641  -14.8595
            292 C1y C    32.9641  -13.4962
            293 C1y C    34.1447  -12.8145
            294 C1y C    35.3255  -13.4962
            295 O2x O    35.3255  -14.8595
            296 C1y C    34.1447  -15.5412
            297 C1b C    34.1447  -17.3184
            298 O1a O    35.3090  -17.9907
            299 O2a O    36.5061  -12.8145
            300 C1y C    37.6867  -13.4962
            301 C1y C    37.6867  -14.8595
            302 C1b C    36.5061  -15.5412
            303 O1a O    36.5061  -16.9044
            304 O2x O    38.8674  -15.5412
            305 C1y C    40.0481  -14.8595
            306 C1y C    40.0481  -13.4962
            307 C1y C    38.8674  -12.8145
            308 O1a O    38.8674  -11.4516
            309 O1a O    41.2326  -12.8123
            310 O2a O    41.2326  -15.5434
            311 C1y C    41.2326  -16.9043
            312 C1y C    40.5511  -18.0850
            313 O2x O    41.2326  -19.2657
            314 C1y C    42.5960  -19.2657
            315 C1y C    43.2776  -18.0850
            316 C1y C    42.5960  -16.9043
            317 O1a O    43.2722  -15.7328
            318 O1a O    44.6202  -18.0846
            319 O2a O    43.2832  -20.4554
            320 C1b C    39.1674  -18.0853
            321 O1a O    38.4955  -19.2496
            322 O1a O    34.1447  -11.4515
            323 O1a O    31.7835  -12.8145
            324 O1a O    29.7442  -15.7334
            325 O1a O    28.3972  -18.0846
            326 O1a O    28.3970  -22.8365
            327 O1a O    29.7459  -25.1659
            328 C1b C    38.5276  -27.5749
            329 O1a O    39.9166  -27.5744
            330 C1b C    40.5451  -20.4871
            331 O1a O    39.1675  -20.4872
            332 C1y C    42.5984  -21.6427
            333 C1y C    41.2126  -21.6427
            334 O2x O    40.5309  -22.8232
            335 C1y C    41.2125  -24.0738
            336 C1y C    42.5983  -24.0040
            337 C1y C    43.2799  -22.8233
            338 O1a O    44.6204  -22.8235
            339 O1a O    43.2695  -25.1671
            340 O2a O    40.5352  -25.1771
            341 C1y C    38.5198  -25.1998
            342 C1y C    37.8384  -26.3805
            343 O2x O    36.4750  -26.3807
            344 C1y C    35.7902  -25.1949
            345 C1y C    36.4716  -24.0141
            346 C1y C    37.8350  -24.0140
            347 O1a O    38.5172  -22.8319
            348 O1a O    35.7736  -22.8047
            349 O2a O    32.4501  -25.1949
            350 C1y C    31.7722  -24.0194
            351 C1y C    30.4089  -24.0185
            352 C1y C    29.7279  -22.8374
            353 C1y C    30.4187  -21.6430
            354 O2x O    31.7819  -21.6439
            355 C1y C    32.4628  -22.8249
            356 C1b C    33.8503  -22.8256
            357 O1a O    34.5286  -21.6523
            358 O2a O    29.7332  -20.4548
            359 C1y C    30.4201  -19.2657
            360 C1y C    29.7384  -18.0850
            361 C1y C    30.4201  -16.9043
            362 C1y C    31.7834  -16.9043
            363 O2x O    32.4651  -18.0850
            364 C1y C    31.7834  -19.2657
            365 C1b C    32.4811  -20.4743
            366 O1a O    33.8501  -20.4746
            367 O2a O    31.7835  -15.5412
            368 C1y C    32.9641  -14.8595
            369 C1y C    32.9641  -13.4962
            370 C1y C    34.1447  -12.8145
            371 C1y C    35.3255  -13.4962
            372 O2x O    35.3255  -14.8595
            373 C1y C    34.1447  -15.5412
            374 C1b C    34.1447  -17.3184
            375 O1a O    35.3090  -17.9907
            376 O2a O    36.5061  -12.8145
            377 C1y C    37.6867  -13.4962
            378 C1y C    37.6867  -14.8595
            379 C1b C    36.5061  -15.5412
            380 O1a O    36.5061  -16.9044
            381 O2x O    38.8674  -15.5412
            382 C1y C    40.0481  -14.8595
            383 C1y C    40.0481  -13.4962
            384 C1y C    38.8674  -12.8145
            385 O1a O    38.8674  -11.4516
            386 O1a O    41.2326  -12.8123
            387 O2a O    41.2326  -15.5434
            388 C1y C    41.2326  -16.9043
            389 C1y C    40.5511  -18.0850
            390 O2x O    41.2326  -19.2657
            391 C1y C    42.5960  -19.2657
            392 C1y C    43.2776  -18.0850
            393 C1y C    42.5960  -16.9043
            394 O1a O    43.2722  -15.7328
            395 O1a O    44.6202  -18.0846
            396 O2a O    43.2832  -20.4554
            397 C1b C    39.1674  -18.0853
            398 O1a O    38.4955  -19.2496
            399 O1a O    34.1447  -11.4515
            400 O1a O    31.7835  -12.8145
            401 O1a O    29.7442  -15.7334
            402 O1a O    28.3972  -18.0846
            403 O1a O    28.3970  -22.8365
            404 O1a O    29.7459  -25.1659
            405 C1b C    38.5276  -27.5749
            406 O1a O    39.9166  -27.5744
            407 C1b C    40.5451  -20.4871
            408 O1a O    39.1675  -20.4872
            409 C8y C    15.3404  -19.4275
            410 C8y C    15.3404  -20.8045
            411 S2x S    16.5421  -21.4930
            412 N4y N    17.6738  -20.8107
            413 C1a C    18.9203  -21.4866
            414 C8y C    17.7313  -19.4213
            415 C5a C    18.9077  -18.7329
            416 O5a O    18.9016  -17.3747
            417 N1b N    20.0916  -19.4083
            418 C8y C    21.2687  -18.7205
            419 N5x N    22.4462  -19.3925
            420 C8x C    23.6231  -18.7047
            421 C8x C    23.6160  -17.3417
            422 C8x C    22.4321  -16.6661
            423 C8x C    21.2553  -17.3539
            424 C8y C    16.5296  -18.7265
            425 O1a O    16.5234  -17.3684
            426 O3c O    14.9899  -22.4631
            427 O3c O    17.9315  -22.4130
            428 C8x C    14.1450  -21.4992
            429 C8x C    12.9684  -20.8045
            430 C8x C    12.9684  -19.4275
            431 C8x C    14.1450  -18.7454
BOND        470
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12    7  12 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   19  24 1
            25   25  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1
            30   25  30 1
            31   32  31 1 #Down
            32   32  33 1
            33   33  34 1 #Up
            34   29  34 1 #Up
            35   32  35 1
            36   35  36 1
            37   36  37 1
            38   37  38 1
            39   33  38 1
            40   25  39 1 #Down
            41   38  40 1 #Down
            42   30  41 1 #Up
            43   26  42 1 #Up
            44   37  43 1 #Up
            45   36  44 1 #Up
            46   31  45 1
            47   19  42 1 #Up
            48   13  44 1 #Up
            49   17  46 1 #Up
            50   16  47 1 #Up
            51   20  48 1 #Up
            52   22  49 1 #Up
            53   21  50 1 #Down
            54   23  51 1 #Down
            55   27  52 1 #Down
            56   14  53 1 #Down
            57   18  54 1 #Down
            58   52  55 1
            59   53  56 1
            60   51  57 1
            61    7  49 1 #Up
            62    1  47 1 #Up
            63    8  58 1 #Up
            64   10  59 1 #Up
            65    4  60 1 #Up
            66    5  61 1 #Up
            67   11  62 1 #Down
            68    9  63 1 #Down
            69    2  64 1 #Down
            70    6  65 1 #Down
            71   64  66 1
            72   62  67 1
            73   68  69 1
            74   69  70 1
            75   70  71 1
            76   71  72 1
            77   72  73 1
            78   68  73 1
            79   71  60 1 #Down
            80   68  59 1 #Down
            81   72  74 1 #Up
            82   70  75 1 #Up
            83   73  76 1 #Down
            84   75  77 1
            85  101 102 1
            86  102 103 1
            87  103 104 1
            88  104 105 1
            89  105 106 1
            90  101 106 1
            91  122 121 1
            92  121 120 1
            93  120 119 1
            94  119 124 1
            95  124 123 1
            96  122 123 1
            97  157 158 1
            98  158 159 1
            99  159 160 1
            100 160 161 1
            101 161 162 1
            102 157 162 1
            103 131 130 1
            104 130 129 1
            105 129 128 1
            106 128 133 1
            107 133 132 1
            108 131 132 1
            109 138 137 1
            110 137 142 1
            111 142 141 1
            112 141 140 1
            113 140 139 1
            114 138 139 1
            115 147 148 1 #Down
            116 147 146 1
            117 146 145 1 #Up
            118 140 145 1 #Up
            119 147 150 1
            120 150 151 1
            121 151 152 1
            122 152 153 1
            123 146 153 1
            124 138 169 1 #Down
            125 153 154 1 #Down
            126 139 168 1 #Up
            127 137 136 1 #Up
            128 152 155 1 #Up
            129 151 156 1 #Up
            130 148 149 1
            131 131 136 1 #Up
            132 157 156 1 #Up
            133 161 164 1 #Up
            134 160 165 1 #Up
            135 130 170 1 #Up
            136 128 127 1 #Up
            137 129 171 1 #Down
            138 133 134 1 #Down
            139 142 143 1 #Down
            140 158 166 1 #Down
            141 162 163 1 #Down
            142 143 144 1
            143 166 167 1
            144 134 135 1
            145 122 127 1 #Up
            146 101 165 1 #Up
            147 121 172 1 #Up
            148 119 118 1 #Up
            149 104 109 1 #Up
            150 105 108 1 #Up
            151 124 125 1 #Down
            152 120 173 1 #Down
            153 102 176 1 #Down
            154 106 107 1 #Down
            155 176 177 1
            156 125 126 1
            157 113 112 1
            158 112 111 1
            159 111 110 1
            160 110 115 1
            161 115 114 1
            162 113 114 1
            163 110 109 1 #Down
            164 113 118 1 #Down
            165 115 116 1 #Up
            166 111 174 1 #Up
            167 114 117 1 #Down
            168 174 175 1
            169 178 179 1
            170 179 180 1
            171 180 181 1
            172 181 182 1
            173 182 183 1
            174 178 183 1
            175 199 198 1
            176 198 197 1
            177 197 196 1
            178 196 201 1
            179 201 200 1
            180 199 200 1
            181 234 235 1
            182 235 236 1
            183 236 237 1
            184 237 238 1
            185 238 239 1
            186 234 239 1
            187 208 207 1
            188 207 206 1
            189 206 205 1
            190 205 210 1
            191 210 209 1
            192 208 209 1
            193 215 214 1
            194 214 219 1
            195 219 218 1
            196 218 217 1
            197 217 216 1
            198 215 216 1
            199 224 225 1 #Down
            200 224 223 1
            201 223 222 1 #Up
            202 217 222 1 #Up
            203 224 227 1
            204 227 228 1
            205 228 229 1
            206 229 230 1
            207 223 230 1
            208 215 246 1 #Down
            209 230 231 1 #Down
            210 216 245 1 #Up
            211 214 213 1 #Up
            212 229 232 1 #Up
            213 228 233 1 #Up
            214 225 226 1
            215 208 213 1 #Up
            216 234 233 1 #Up
            217 238 241 1 #Up
            218 237 242 1 #Up
            219 207 247 1 #Up
            220 205 204 1 #Up
            221 206 248 1 #Down
            222 210 211 1 #Down
            223 219 220 1 #Down
            224 235 243 1 #Down
            225 239 240 1 #Down
            226 220 221 1
            227 243 244 1
            228 211 212 1
            229 199 204 1 #Up
            230 178 242 1 #Up
            231 198 249 1 #Up
            232 196 195 1 #Up
            233 181 186 1 #Up
            234 182 185 1 #Up
            235 201 202 1 #Down
            236 197 250 1 #Down
            237 179 253 1 #Down
            238 183 184 1 #Down
            239 253 254 1
            240 202 203 1
            241 190 189 1
            242 189 188 1
            243 188 187 1
            244 187 192 1
            245 192 191 1
            246 190 191 1
            247 187 186 1 #Down
            248 190 195 1 #Down
            249 192 193 1 #Up
            250 188 251 1 #Up
            251 191 194 1 #Down
            252 251 252 1
            253 255 256 1
            254 256 257 1
            255 257 258 1
            256 258 259 1
            257 259 260 1
            258 255 260 1
            259 276 275 1
            260 275 274 1
            261 274 273 1
            262 273 278 1
            263 278 277 1
            264 276 277 1
            265 311 312 1
            266 312 313 1
            267 313 314 1
            268 314 315 1
            269 315 316 1
            270 311 316 1
            271 285 284 1
            272 284 283 1
            273 283 282 1
            274 282 287 1
            275 287 286 1
            276 285 286 1
            277 292 291 1
            278 291 296 1
            279 296 295 1
            280 295 294 1
            281 294 293 1
            282 292 293 1
            283 301 302 1 #Down
            284 301 300 1
            285 300 299 1 #Up
            286 294 299 1 #Up
            287 301 304 1
            288 304 305 1
            289 305 306 1
            290 306 307 1
            291 300 307 1
            292 292 323 1 #Down
            293 307 308 1 #Down
            294 293 322 1 #Up
            295 291 290 1 #Up
            296 306 309 1 #Up
            297 305 310 1 #Up
            298 302 303 1
            299 285 290 1 #Up
            300 311 310 1 #Up
            301 315 318 1 #Up
            302 314 319 1 #Up
            303 284 324 1 #Up
            304 282 281 1 #Up
            305 283 325 1 #Down
            306 287 288 1 #Down
            307 296 297 1 #Down
            308 312 320 1 #Down
            309 316 317 1 #Down
            310 297 298 1
            311 320 321 1
            312 288 289 1
            313 276 281 1 #Up
            314 255 319 1 #Up
            315 275 326 1 #Up
            316 273 272 1 #Up
            317 258 263 1 #Up
            318 259 262 1 #Up
            319 278 279 1 #Down
            320 274 327 1 #Down
            321 256 330 1 #Down
            322 260 261 1 #Down
            323 330 331 1
            324 279 280 1
            325 267 266 1
            326 266 265 1
            327 265 264 1
            328 264 269 1
            329 269 268 1
            330 267 268 1
            331 264 263 1 #Down
            332 267 272 1 #Down
            333 269 270 1 #Up
            334 265 328 1 #Up
            335 268 271 1 #Down
            336 328 329 1
            337 332 333 1
            338 333 334 1
            339 334 335 1
            340 335 336 1
            341 336 337 1
            342 332 337 1
            343 353 352 1
            344 352 351 1
            345 351 350 1
            346 350 355 1
            347 355 354 1
            348 353 354 1
            349 388 389 1
            350 389 390 1
            351 390 391 1
            352 391 392 1
            353 392 393 1
            354 388 393 1
            355 362 361 1
            356 361 360 1
            357 360 359 1
            358 359 364 1
            359 364 363 1
            360 362 363 1
            361 369 368 1
            362 368 373 1
            363 373 372 1
            364 372 371 1
            365 371 370 1
            366 369 370 1
            367 378 379 1 #Down
            368 378 377 1
            369 377 376 1 #Up
            370 371 376 1 #Up
            371 378 381 1
            372 381 382 1
            373 382 383 1
            374 383 384 1
            375 377 384 1
            376 369 400 1 #Down
            377 384 385 1 #Down
            378 370 399 1 #Up
            379 368 367 1 #Up
            380 383 386 1 #Up
            381 382 387 1 #Up
            382 379 380 1
            383 362 367 1 #Up
            384 388 387 1 #Up
            385 392 395 1 #Up
            386 391 396 1 #Up
            387 361 401 1 #Up
            388 359 358 1 #Up
            389 360 402 1 #Down
            390 364 365 1 #Down
            391 373 374 1 #Down
            392 389 397 1 #Down
            393 393 394 1 #Down
            394 374 375 1
            395 397 398 1
            396 365 366 1
            397 353 358 1 #Up
            398 332 396 1 #Up
            399 352 403 1 #Up
            400 350 349 1 #Up
            401 335 340 1 #Up
            402 336 339 1 #Up
            403 355 356 1 #Down
            404 351 404 1 #Down
            405 333 407 1 #Down
            406 337 338 1 #Down
            407 407 408 1
            408 356 357 1
            409 344 343 1
            410 343 342 1
            411 342 341 1
            412 341 346 1
            413 346 345 1
            414 344 345 1
            415 341 340 1 #Down
            416 344 349 1 #Down
            417 346 347 1 #Up
            418 342 405 1 #Up
            419 345 348 1 #Down
            420 405 406 1
            421  80  85 1
            422  81  86 2
            423  82  87 1
            424  82  88 2
            425  82  89 2
            426  83  90 2
            427  84  91 1
            428  87  92 1
            429  91  93 2
            430  84  87 1
            431  86  90 1
            432  91  94 1
            433  78  79 2
            434  94  95 1
            435  78  80 1
            436  78  81 1
            437  79  82 1
            438  79  83 1
            439  80  84 2
            440  95  96 2
            441  96  97 1
            442  97  98 2
            443  98  99 1
            444  99 100 2
            445 100  95 1
            446 424 425 1
            447 431 430 2
            448 411 412 1
            449 411 426 2
            450 411 427 2
            451 428 429 2
            452 414 415 1
            453 412 413 1
            454 415 416 2
            455 414 412 1
            456 430 429 1
            457 415 417 1
            458 409 410 2
            459 417 418 1
            460 409 424 1
            461 409 431 1
            462 410 411 1
            463 410 428 1
            464 424 414 2
            465 418 419 2
            466 419 420 1
            467 420 421 2
            468 421 422 1
            469 422 423 2
            470 423 418 1
BRACKET     1    27.0200  -28.3500   27.0200  -10.9200
            1    46.9700  -10.9200   46.9700  -28.3500
            1  5
 ORIGINAL  1    1   2   3   4   5   6  65  61  60  71  70  69  68  73  72  74
            1   76  59  10   9   8   7  12  11  62  67  49  22  21  20  19  24
            1   23  51  57  42  26  25  30  29  28  27  52  55  34  33  32  31
            1   45  35  36  37  38  40  43  44  13  14  15  16  17  18  54  46
            1   47  53  56  41  39  48  50  58  63  75  77  64  66
 REPEAT    1  101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116
            1  117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132
            1  133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148
            1  149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164
            1  165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180
            1  181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196
            1  197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212
            1  213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228
            1  229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244
            1  245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260
            1  261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276
            1  277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292
            1  293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308
            1  309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324
            1  325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340
            1  341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356
            1  357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372
            1  373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388
            1  389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404
            1  405 406 407 408
            2    12.8100  -23.3800   12.8100  -16.4500
            2    24.2200  -16.4500   24.2200  -23.3800
            2  2
 ORIGINAL  2   78  79  82  87  92  84  91  93  94  95  96  97  98  99 100  80
            2   85  88  89  83  90  86  81
 REPEAT    2  409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424
            2  425 426 427 428 429 430 431

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