KEGG   DRUG: Piroxicam cinnamate
Entry
D05512                      Drug                                   

Name
Piroxicam cinnamate (USAN)
Formula
C24H19N3O5S
Exact mass
461.1045
Mol weight
461.4898
Structure
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
 DG01910  Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: M01AC01 M02AA07 S01BC06
Chemical structure group: DG00752
Product (DG00752): D00127<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Oxicams
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC01 Piroxicam
      D05512  Piroxicam cinnamate (USAN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA07 Piroxicam
      D05512  Piroxicam cinnamate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC06 Piroxicam
      D05512  Piroxicam cinnamate (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D05512  Piroxicam cinnamate (USAN)
    PTGS2 (COX2)
     D05512  Piroxicam cinnamate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05512
Other DBs
CAS: 87234-24-0
PubChem: 47207181
ChEMBL: CHEMBL2106889
DrugBank: DB00554
LigandBox: D05512
LinkDB
KCF data

ATOM        33
            1   C8y C    21.6404  -19.0775
            2   C8y C    21.6404  -20.4545
            3   C8y C    22.8296  -18.3765
            4   C8x C    20.4450  -18.3954
            5   S2x S    22.8421  -21.1430
            6   C8x C    20.4450  -21.1492
            7   C8y C    24.0313  -19.0713
            8   O7a O    22.8234  -17.0184
            9   C8x C    19.2684  -19.0775
            10  N4y N    24.0438  -20.4607
            11  O3c O    21.2899  -22.1131
            12  O3c O    24.2315  -22.0630
            13  C8x C    19.2684  -20.4545
            14  C5a C    25.2077  -18.3829
            15  C1a C    25.2203  -21.1366
            16  O5a O    25.2016  -17.0247
            17  N1b N    26.3916  -19.0583
            18  C8y C    27.5687  -18.3705
            19  N5x N    28.7462  -19.0425
            20  C8x C    29.9231  -18.3547
            21  C8x C    29.9160  -16.9917
            22  C8x C    28.7321  -16.3161
            23  C8x C    27.5553  -17.0039
            24  C7a C    21.6016  -16.3205
            25  O6a O    21.6649  -14.9104
            26  C2b C    20.4016  -16.9816
            27  C2b C    19.1936  -16.2510
            28  C8y C    17.9615  -16.9295
            29  C8x C    16.7891  -16.2204
            30  C8x C    15.5627  -16.8956
            31  C8x C    15.5342  -18.2953
            32  C8x C    16.7067  -19.0044
            33  C8x C    18.0031  -18.3292
BOND        36
            1     3   8 1
            2     4   9 2
            3     5  10 1
            4     5  11 2
            5     5  12 2
            6     6  13 2
            7     7  14 1
            8    10  15 1
            9    14  16 2
            10    7  10 1
            11    9  13 1
            12   14  17 1
            13    1   2 2
            14   17  18 1
            15    1   3 1
            16    1   4 1
            17    2   5 1
            18    2   6 1
            19    3   7 2
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  18 1
            26    8  24 1
            27   24  25 2
            28   24  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1

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