KEGG   DRUG: Piroxicam olamine
Entry
D05513                      Drug                                   

Name
Piroxicam olamine (USAN)
Formula
C15H13N3O4S. C2H7NO
Exact mass
392.1154
Mol weight
392.4295
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
 DG01910  Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: M01AC01 M02AA07 S01BC06
Chemical structure group: DG00752
Product (DG00752): D00127<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Oxicams
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC01 Piroxicam
      D05513  Piroxicam olamine (USAN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA07 Piroxicam
      D05513  Piroxicam olamine (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC06 Piroxicam
      D05513  Piroxicam olamine (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D05513  Piroxicam olamine (USAN)
    PTGS2 (COX2)
     D05513  Piroxicam olamine (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05513
Other DBs
CAS: 85056-47-9
PubChem: 47207182
ChEMBL: CHEMBL2106953
DrugBank: DB00554
LigandBox: D05513
LinkDB
KCF data

ATOM        27
            1   C8y C     5.3304   -7.8075
            2   C8y C     5.3304   -9.1845
            3   C8y C     6.5196   -7.1065
            4   C8x C     4.1350   -7.1254
            5   S2x S     6.5321   -9.8730
            6   C8x C     4.1350   -9.8792
            7   C8y C     7.7213   -7.8013
            8   O1a O     6.5134   -5.7484
            9   C8x C     2.9584   -7.8075
            10  N4y N     7.7338   -9.1907
            11  O3c O     4.9799  -10.8431
            12  O3c O     7.9215  -10.7930
            13  C8x C     2.9584   -9.1845
            14  C5a C     8.8977   -7.1129
            15  C1a C     8.9103   -9.8666
            16  O5a O     8.8916   -5.7547
            17  N1b N    10.0816   -7.7883
            18  C8y C    11.2587   -7.1005
            19  N5x N    12.4362   -7.7725
            20  C8x C    13.6131   -7.0847
            21  C8x C    13.6060   -5.7217
            22  C8x C    12.4221   -5.0461
            23  C8x C    11.2453   -5.7339
            24  C1b C    17.7570   -9.0302
            25  C1b C    16.5415   -8.3288
            26  N1a N    18.9667   -8.3288
            27  O1a O    15.3318   -9.0302
BOND        28
            1     3   8 1
            2     4   9 2
            3     5  10 1
            4     5  11 2
            5     5  12 2
            6     6  13 2
            7     7  14 1
            8    10  15 1
            9    14  16 2
            10    7  10 1
            11    9  13 1
            12   14  17 1
            13    1   2 2
            14   17  18 1
            15    1   3 1
            16    1   4 1
            17    2   5 1
            18    2   6 1
            19    3   7 2
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  18 1
            26   24  25 1
            27   24  26 1
            28   25  27 1

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