| Entry |
|
|---|
| Name |
Rotigotine (JAN/USAN/INN);
Neupro (TN) |
|---|
| Product |
|
|---|
| Formula |
C19H25NOS
|
|---|
| Exact mass |
315.1657
|
|---|
| Mol weight |
315.4729
|
|---|
| Structure |
|
|---|
| Class |
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiparkinsonian, Dopamine D2 receptor agonist |
|---|
| Disease |
Parkinson disease [DS: H00057] Restless legs syndrome [DS: H01597] |
|---|
| Comment |
Treatment of early and advanced Parkinson's disease and restless legs syndrome
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BC Dopamine agonists
N04BC09 Rotigotine
D05768 Rotigotine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
Dopamine Agonists
Rotigotine
D05768 Rotigotine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
116 Antiparkinsonian agents
1169 Others
D05768 Rotigotine (JAN/USAN/INN)
119 Miscellaneous
1190 Miscellaneous
D05768 Rotigotine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D05768 Rotigotine (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D05768
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D05768
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D05768
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D05768
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05768
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 C8x C 26.0995 -16.8025
2 C8x C 26.0995 -18.2078
3 C8y C 27.3165 -18.9104
4 C8y C 28.5336 -18.2078
5 C8y C 28.5336 -16.8025
6 C8x C 27.3165 -16.0998
7 C1x C 29.7506 -18.9104
8 C1x C 30.9676 -18.2078
9 C1y C 30.9676 -16.8025
10 C1x C 29.7506 -16.0998
11 N1c N 32.1697 -16.1083
12 O1a O 27.3165 -20.3155
13 C1b C 33.3625 -16.7970
14 C1b C 32.1698 -14.6948
15 C1b C 33.3662 -14.0039
16 C1a C 34.5560 -14.6908
17 C1b C 34.5578 -16.1067
18 C8y C 35.7519 -16.7961
19 C8x C 35.8030 -18.2026
20 C8x C 37.1574 -18.5894
21 C8x C 37.9438 -17.4208
22 S2x S 37.0754 -16.3117
BOND 24
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1 #Up
13 3 12 1
14 11 13 1
15 11 14 1
16 14 15 1
17 15 16 1
18 13 17 1
19 17 18 1
20 18 19 2
21 19 20 1
22 20 21 2
23 21 22 1
24 18 22 1
|
|---|
