| Entry |
|
|---|
| Name |
Rufinamide (JAN/USP/INN);
Banzel (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C10H8F2N4O
|
|---|
| Exact mass |
238.0666
|
|---|
| Mol weight |
238.1935
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG02034 Carboxamide antiepileptics
|
|---|
| Remark |
| Therapeutic category: | 1139 |
|
|---|
| Efficacy |
Antiepileptic |
|---|
| Disease |
Lennox-Gastaut syndrome [DS: H01813] |
|---|
| Comment |
Carboxamide derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AF Carboxamide derivatives
N03AF03 Rufinamide
D05775 Rufinamide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Sodium Channel Agents
Rufinamide
D05775 Rufinamide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D05775 Rufinamide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN2A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN3A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN4A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN5A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN8A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN9A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN10A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
SCN11A
D05775 Rufinamide (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D05775
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D05775
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D05775
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D05775
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05775
|
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| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 17
1 C8x C 27.5379 -17.1661
2 C8x C 27.5379 -18.5624
3 C8x C 28.7471 -19.2605
4 C8y C 29.9564 -18.5624
5 C8y C 29.9564 -17.1661
6 C8y C 28.7471 -16.4679
7 X F 28.7471 -15.0718
8 X F 31.1843 -19.2715
9 C1b C 31.1843 -16.4570
10 N4y N 32.3863 -17.1508
11 N5x N 32.4321 -18.5562
12 N5x N 33.7844 -18.9475
13 C8y C 34.5745 -17.7822
14 C8x C 33.7104 -16.6707
15 C5a C 35.9312 -17.8076
16 N1a N 36.5583 -19.0940
17 O5a O 36.6991 -16.6707
BOND 18
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 4 8 1
9 5 9 1
10 9 10 1
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 10 14 1
16 13 15 1
17 15 16 1
18 15 17 2
|
|---|
