KEGG   DRUG: Triamcinolone acetonide sodium phosphate
Entry
D06216                      Drug                                   

Name
Triamcinolone acetonide sodium phosphate (USAN)
Formula
C24H30FO9P. 2Na
Exact mass
558.1407
Mol weight
558.4413
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05
Chemical structure group: DG00010
Product (DG00010): D00385<JP> D00983<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC01 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA12 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB09 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB02 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB08 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD11 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA06 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA05 Triamcinolone
      D06216  Triamcinolone acetonide sodium phosphate (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D06216  Triamcinolone acetonide sodium phosphate (USAN)
Other DBs
CAS: 1997-15-5
PubChem: 47207874
ChEMBL: CHEMBL3989672
DrugBank: DB00620
LigandBox: D06216
NIKKAJI: J7.844A
LinkDB
KCF data

ATOM        37
            1   Z   Na   24.3661  -22.1928 #+
            2   Z   Na   18.6951  -22.6834 #+
            3   C2x C    18.8300  -28.6300
            4   C5x C    18.8300  -29.9600
            5   C2x C    20.0200  -30.6600
            6   C2y C    21.1400  -29.9600
            7   C1z C    21.1400  -28.6300
            8   C2x C    20.0200  -28.0000
            9   C1x C    22.3300  -30.6600
            10  C1x C    23.5200  -29.9600
            11  C1y C    23.5200  -28.6300
            12  C1z C    22.3300  -28.0000
            13  C1y C    24.5700  -28.0000
            14  C1z C    24.5700  -26.6700
            15  C1x C    23.5200  -25.9700
            16  C1y C    22.3300  -26.6700
            17  C1x C    26.8800  -28.0000
            18  C1y C    26.8800  -26.6700
            19  C1z C    25.6900  -25.9700
            20  O5x O    17.7100  -30.6600
            21  C1a C    21.1400  -27.3000
            22  X   F    22.3300  -29.2600
            23  O1a O    21.1400  -25.9700
            24  C1a C    24.5700  -25.2700
            25  C5a C    25.6900  -24.1500
            26  O2x O    27.0900  -25.0600
            27  O2x O    28.2800  -26.6700
            28  C1z C    28.4900  -25.0600
            29  C1a C    29.8200  -25.0600
            30  C1a C    28.4900  -23.8000
            31  O5a O    26.8800  -23.4500
            32  C1b C    24.5000  -23.4500
            33  O2b O    23.3100  -24.1500
            34  P1b P    22.0919  -23.4599
            35  O1c O    20.8795  -22.7599 #-
            36  O1c O    22.7919  -22.2474 #-
            37  O1c O    21.3219  -24.7423
BOND        39
            1     3   4 1
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 1
            6     3   8 2
            7     6   9 1
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11    7  12 1
            12   11  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   12  16 1
            17   13  17 1
            18   17  18 1
            19   18  19 1
            20   14  19 1
            21    4  20 2
            22    7  21 1 #Up
            23   12  22 1 #Down
            24   16  23 1 #Up
            25   14  24 1 #Up
            26   19  25 1 #Up
            27   19  26 1 #Down
            28   18  27 1 #Down
            29   26  28 1
            30   28  27 1
            31   28  29 1
            32   28  30 1
            33   25  31 2
            34   25  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   34  36 1
            39   34  37 2

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