| Entry |
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| Name |
Fosaprepitant dimeglumine (USAN);
Fosaprepitant meglumine (JAN);
Proemend (TN) |
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| Product |
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| Generic |
FOSAPREPITANT (Accord Healthcare), FOSAPREPITANT (Athenex Pharmaceutical Division), FOSAPREPITANT (Avenacy), FOSAPREPITANT (BE Pharmaceuticals), FOSAPREPITANT (Baxter Healthcare Corporation), FOSAPREPITANT (BluePoint Laboratories), FOSAPREPITANT (BluePoint Laboratories), FOSAPREPITANT (BluePoint Laboratories), FOSAPREPITANT (Camber Pharmaceuticals), FOSAPREPITANT (Chia Tai Tianqing Pharmaceutical Group), FOSAPREPITANT (Cipla USA), FOSAPREPITANT (Dr. Reddy's Laboratories Inc.,), FOSAPREPITANT (Dr. Reddy's Laboratories Inc.,), FOSAPREPITANT (Fresenius Kabi USA), FOSAPREPITANT (Hepalink USA), FOSAPREPITANT (MSN LABORATORIES PRIVATE LIMITED), FOSAPREPITANT (MSN LABORATORIES PRIVATE LIMITED), FOSAPREPITANT (Mylan Institutional LLC), FOSAPREPITANT (NorthStar RxLLC), FOSAPREPITANT (NorthStar RxLLC), FOSAPREPITANT (NorthStar RxLLC), FOSAPREPITANT (Novadoz Pharmaceuticals LLC), FOSAPREPITANT (Novadoz Pharmaceuticals LLC), FOSAPREPITANT (Novadoz Pharmaceuticals LLC), FOSAPREPITANT (Zydus Pharmaceuticals USA), FOSAPREPITANT DIMEGLUMINE (Eugia US LLC), FOSAPREPITANT DIMEGLUMINE (Hikma Pharmaceuticals USA), FOSAPREPITANT DIMEGLUMINE (Hikma Pharmaceuticals USA), FOSAPREPITANT DIMEGLUMINE (Qilu Pharmaceutical), FOSAPREPITANT DIMEGLUMINE (Sandoz) |
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| Formula |
C23H22F7N4O6P. (C7H17NO5)2
|
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| Exact mass |
1004.3379
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| Mol weight |
1004.8337
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| Structure |
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| Class |
Gastrointestinal agent
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
Metabolizing enzyme inducer
DG02886 CYP2C9 inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Therapeutic category: | 2391 |
| Product (DG00066): | D02968<JP/US> D06597<JP/US> |
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| Efficacy |
Anti-emetic, Neurokinin NK1 antagonist |
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| Comment |
Active form of prodrug: Aprepitant [DR: D02968]
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576], CYP2C9 [HSA: 1559]
CYP inhibition: CYP3A4 [HSA: 1576]
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AD Other antiemetics
A04AD12 Aprepitant
D06597 Fosaprepitant dimeglumine (USAN) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Emetogenic Therapy Adjuncts
Aprepitant
D06597 Fosaprepitant dimeglumine (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2391 Antiemetics
D06597 Fosaprepitant dimeglumine (USAN); Fosaprepitant meglumine (JAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01762 Antiemetic
DG00066 Aprepitant
D06597 Fosaprepitant dimeglumine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00066 Aprepitant
D06597 Fosaprepitant dimeglumine
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00066 Aprepitant
D06597 Fosaprepitant dimeglumine
Metabolizing enzyme inducer
DG02886 CYP2C9 inducer
DG00066 Aprepitant
D06597 Fosaprepitant dimeglumine
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00066 Aprepitant
D06597 Fosaprepitant dimeglumine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Tachykinin
TACR1 (NK1R)
D06597 Fosaprepitant dimeglumine (USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D06597
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D06597
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D06597
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06597
Prodrugs [br08324.html]
D06597
Drug groups [BR:br08330]
Gastrointestinal agent
DG01762 Antiemetic
DG00066 Aprepitant
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00066 Aprepitant
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00066 Aprepitant
Metabolizing enzyme inducer
DG02886 CYP2C9 inducer
DG00066 Aprepitant
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00066 Aprepitant
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 67
1 C1y C 49.9427 -15.8889
2 C1y C 48.7520 -16.5766
3 C8y C 53.5367 -16.5837
4 C8x C 53.5367 -17.9831
5 C8y C 54.7486 -18.6829
6 C8x C 55.9607 -17.9831
7 C8y C 55.9607 -16.5837
8 C8x C 54.7486 -15.8839
9 C1d C 57.1913 -15.8729
10 C1d C 54.7486 -20.0821
11 X F 54.7486 -21.4816
12 X F 53.3268 -20.0821
13 X F 56.1257 -20.0821
14 X F 58.4032 -15.1732
15 X F 56.4923 -14.6625
16 X F 57.8918 -17.0861
17 C1c C 52.3248 -15.8839
18 O2a O 51.1297 -16.5741
19 C1a C 52.3247 -14.4846
20 O2x O 49.9425 -14.4893
21 C1x C 48.7305 -13.7899
22 C1x C 47.5398 -14.4776
23 N1y N 47.5400 -15.8770
24 C8y C 48.7520 -17.9829
25 C8x C 47.5600 -18.6715
26 C8x C 47.5603 -20.0709
27 C8y C 48.7724 -20.7704
28 C8x C 49.9645 -20.0818
29 C8x C 49.9642 -18.6824
30 X F 48.7726 -22.1815
31 C1b C 46.3070 -16.5837
32 C8y C 45.0950 -15.8839
33 N4x N 45.0948 -14.4614
34 C8y C 43.7418 -14.0219
35 N4y N 42.9058 -15.1728
36 N5x N 43.7420 -16.3236
37 O5x O 43.3127 -12.7027
38 P1b P 41.5101 -15.1730
39 O1c O 40.1101 -15.1730
40 O1c O 41.5102 -16.5900
41 O1c O 41.5100 -13.7900
42 C1a C 35.3936 -20.4602
43 N1b N 36.6047 -19.7614
44 C1b C 37.8159 -20.4602
45 C1c C 39.0269 -19.7614
46 C1c C 40.2381 -20.4602
47 C1c C 41.4493 -19.7614
48 C1c C 42.6604 -20.4602
49 C1b C 43.8715 -19.8080
50 O1a O 45.0828 -20.5067
51 O1a O 39.0269 -18.3639
52 O1a O 40.2381 -21.8576
53 O1a O 41.4493 -18.3639
54 O1a O 42.6604 -21.9041
55 C1a C 35.3936 -20.4602
56 N1b N 36.6047 -19.7614
57 C1b C 37.8159 -20.4602
58 C1c C 39.0269 -19.7614
59 C1c C 40.2381 -20.4602
60 O1a O 40.2381 -21.8576
61 C1c C 41.4493 -19.7614
62 C1c C 42.6604 -20.4602
63 C1b C 43.8715 -19.8080
64 O1a O 45.0828 -20.5067
65 O1a O 42.6604 -21.9041
66 O1a O 41.4493 -18.3639
67 O1a O 39.0269 -18.3639
BOND 68
1 1 2 1
2 3 4 2
3 4 5 1
4 5 6 2
5 6 7 1
6 7 8 2
7 3 8 1
8 7 9 1
9 5 10 1
10 10 11 1
11 10 12 1
12 10 13 1
13 9 14 1
14 9 15 1
15 9 16 1
16 3 17 1
17 17 18 1
18 17 19 1 #Down
19 1 18 1 #Down
20 1 20 1
21 20 21 1
22 21 22 1
23 22 23 1
24 2 23 1
25 2 24 1 #Down
26 24 25 2
27 25 26 1
28 26 27 2
29 27 28 1
30 28 29 2
31 24 29 1
32 27 30 1
33 23 31 1
34 31 32 1
35 32 33 1
36 33 34 1
37 34 35 1
38 35 36 1
39 32 36 2
40 34 37 2
41 35 38 1
42 38 39 2
43 38 40 1
44 38 41 1
45 47 48 1
46 44 45 1
47 48 49 1
48 49 50 1
49 45 46 1
50 45 51 1 #Down
51 43 44 1
52 46 52 1 #Down
53 46 47 1
54 47 53 1 #Down
55 42 43 1
56 48 54 1 #Up
57 61 62 1
58 57 58 1
59 62 63 1
60 63 64 1
61 58 59 1
62 58 67 1 #Down
63 56 57 1
64 59 60 1 #Down
65 59 61 1
66 61 66 1 #Down
67 55 56 1
68 62 65 1 #Up
BRACKET 1 33.6700 -22.4000 33.6700 -17.8500
1 46.3400 -17.8500 46.3400 -22.4000
1 2
ORIGINAL 1 42 43 44 45 46 52 47 48 49 50 54 53 51
REPEAT 1 55 56 57 58 59 60 61 62 63 64 65 66 67
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