KEGG   DRUG: Yohimbine hydrochloride
Entry
D06671                      Drug                                   

Name
Yohimbine hydrochloride (USP)
Formula
C21H26N2O3. HCl
Exact mass
390.171
Mol weight
390.9037
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Remark
ATC code: G04BE04
Chemical structure group: DG00485
Efficacy
alpha2-Adrenergic receptor antagonist
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE04 Yohimbin
      D06671  Yohimbine hydrochloride (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  31 Other drugs for  urogenital organs and anus
   D06671  Yohimbine hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Drugs requiring guidance
  Powerful drugs
   Yohimbine
    D06671  Yohimbine hydrochloride (USP)
 First-class OTC drugs
  Inorganic and organic chemicals
   Yohimbine
    D06671  Yohimbine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D06671  Yohimbine hydrochloride (USP)
Other DBs
CAS: 65-19-0
PubChem: 47208322
ChEMBL: CHEMBL537669
LigandBox: D06671
NIKKAJI: J237.516H
LinkDB
KCF data

ATOM        27
            1   C8x C    21.2100  -16.4500
            2   C8x C    21.2100  -17.7800
            3   C8x C    22.4700  -18.4800
            4   C8x C    22.4000  -15.6800
            5   C8y C    23.5900  -16.3800
            6   C8y C    23.5900  -17.7100
            7   C1x C    26.8100  -14.3500
            8   C1x C    25.4100  -14.5600
            9   N1y N    27.6500  -15.4700
            10  C1y C    27.0900  -16.7300
            11  C1x C    28.0000  -17.8500
            12  C1x C    28.9800  -15.2600
            13  C1y C    29.8900  -16.3800
            14  C1y C    29.3300  -17.6400
            15  C1y C    30.1700  -18.6900
            16  C1y C    31.5700  -18.5500
            17  C1x C    32.0600  -17.2200
            18  C1x C    31.2200  -16.1700
            19  C8y C    25.7600  -16.9400
            20  C8y C    24.9200  -15.8900
            21  N4x N    24.9900  -18.1300
            22  C7a C    29.6271  -19.9805
            23  O6a O    28.2255  -20.1575
            24  O7a O    30.4526  -21.0681
            25  C1a C    31.8388  -20.8931
            26  O1a O    32.4270  -19.6571
            27  X   Cl   34.9300  -17.4300
BOND        30
            1     1   2 1
            2    19  10 1
            3     9   7 1
            4     7   8 1
            5    13  14 1
            6    14  15 1
            7    15  16 1
            8    16  17 1
            9    17  18 1
            10   18  13 1
            11    8  20 1
            12    2   3 2
            13    3   6 1
            14    5   4 1
            15   19  20 2
            16   20   5 1
            17    6  21 1
            18   21  19 1
            19    4   1 2
            20    9  10 1
            21   10  11 1
            22   11  14 1
            23   13  12 1
            24   12   9 1
            25    5   6 2
            26   15  22 1 #Down
            27   22  23 2
            28   22  24 1
            29   24  25 1
            30   16  26 1 #Down

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