Entry |
|
Name |
Methylprednisolone aceponate (INN); Advantan (TN) |
Formula |
C27H36O7
|
Exact mass |
472.2461
|
Mol weight |
472.5705
|
Structure |
|
Simcomp |
|
Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Product (DG00410): | D00407<JP/US> D00751<JP/US> D00979<JP/US> |
|
Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Structure map |
map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA01 Methylprednisolone
D07203 Methylprednisolone aceponate (INN)
D07AC Corticosteroids, potent (group III)
D07AC14 Methylprednisolone aceponate
D07203 Methylprednisolone aceponate (INN)
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA02 Methylprednisolone
D07203 Methylprednisolone aceponate (INN)
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB04 Methylprednisolone
D07203 Methylprednisolone aceponate (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
D07203 Methylprednisolone aceponate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
D07203 Methylprednisolone aceponate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07203 Methylprednisolone aceponate (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07203
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 34
1 C1z C 27.4416 -18.9534
2 C1y C 27.4416 -20.3466
3 C1x C 29.8101 -20.3466
4 C1x C 29.8101 -18.9534
5 C1z C 28.6259 -18.2568
6 C1x C 26.2574 -18.2568
7 C1y C 25.0731 -18.9534
8 C1y C 25.0731 -20.3466
9 C1y C 26.2574 -21.0433
10 C1z C 23.8889 -21.0433
11 C2y C 23.8889 -22.3668
12 C1y C 25.0731 -22.9938
13 C1x C 26.2574 -22.3668
14 C2x C 22.7046 -20.3466
15 C2x C 21.5204 -21.0433
16 C5x C 21.5204 -22.3668
17 C2x C 22.7046 -22.9938
18 C1a C 27.4416 -17.6298
19 O1a O 23.8889 -18.2568
20 C1a C 23.8889 -19.6500
21 O5x O 20.4058 -22.9938
22 C5a C 28.6259 -16.8635
23 O7a O 29.8353 -17.5650
24 C1b C 29.8324 -16.1669
25 O7a O 29.8324 -14.7737
26 C7a C 31.0222 -14.0866
27 C1a C 31.0222 -12.6934
28 C7a C 31.0181 -18.2545
29 C1b C 32.2086 -17.5735
30 C1a C 33.3841 -18.2587
31 O6a O 31.0124 -19.6499
32 O5a O 27.4194 -16.1669
33 O6a O 32.2037 -14.7688
34 C1a C 25.0728 -24.3599
BOND 37
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 1 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 9 2 1
11 8 10 1
12 10 11 1
13 11 12 1
14 12 13 1
15 13 9 1
16 10 14 1
17 14 15 2
18 15 16 1
19 16 17 1
20 17 11 2
21 1 18 1 #Up
22 7 19 1 #Up
23 10 20 1 #Up
24 16 21 2
25 5 22 1 #Up
26 5 23 1 #Down
27 22 24 1
28 24 25 1
29 25 26 1
30 26 27 1
31 23 28 1
32 28 29 1
33 29 30 1
34 28 31 2
35 22 32 2
36 26 33 2
37 12 34 1 #Down
|