KEGG   DRUG: Benzydamine salicylate
Entry
D07517                      Drug                                   

Name
Benzydamine salicylate;
Fulgium (TN)
Formula
C19H23N3O. C7H6O3
Exact mass
447.2158
Mol weight
447.5262
Structure
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
Remark
ATC code: A01AD02 G02CC03 M01AX07 M02AA05 R02AX03
Chemical structure group: DG00014
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Benzimidazole derivative
non-steroidal anti-inflammatory drug (NSAID)
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
ALOX5 [HSA:240] [KO:K00461]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD02 Benzydamine (except lozenges)
      D07517  Benzydamine salicylate
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC03 Benzydamine
      D07517  Benzydamine salicylate
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX07 Benzydamine
      D07517  Benzydamine salicylate
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA05 Benzydamine
      D07517  Benzydamine salicylate
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX03 Benzydamine (only lozenges)
      D07517  Benzydamine salicylate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dioxygenases
    ALOX5
     D07517  Benzydamine salicylate
   Prostaglandin synthase
    PTGS1 (COX1)
     D07517  Benzydamine salicylate
    PTGS2 (COX2)
     D07517  Benzydamine salicylate
Other DBs
CAS: 59831-61-7
PubChem: 51091840
LigandBox: D07517
NIKKAJI: J300.642E
LinkDB
KCF data

ATOM        33
            1   C8x C     7.1743   -8.7711
            2   C8x C     5.9174   -8.0728
            3   C8x C     5.9174   -6.6763
            4   C8x C     7.1743   -5.9781
            5   C8y C     8.3613   -8.0728
            6   C8y C     8.3613   -6.6763
            7   N4y N     9.6879   -6.1876
            8   N5x N    10.5258   -7.3746
            9   C8y C     9.6879   -8.4918
            10  C1b C    10.5258   -5.0704
            11  C8y C    11.9223   -5.0704
            12  C8x C    12.6205   -6.3272
            13  C8x C    14.0170   -6.3272
            14  C8x C    14.7153   -5.0704
            15  C8x C    14.0170   -3.8834
            16  C8x C    12.6205   -3.8834
            17  O2a O     9.6879   -9.8883
            18  C1b C    10.8749  -10.5865
            19  C1b C    12.1318   -9.8883
            20  C1b C    13.2490  -10.5865
            21  N1c N    14.5058   -9.8883
            22  C1a C    15.6928  -10.5865
            23  C1a C    14.5058   -8.4918
            24  C8x C    19.0400   -7.7700
            25  C8x C    19.0400   -9.1700
            26  C8x C    20.2300   -9.8700
            27  C8x C    21.4200   -9.1700
            28  C8y C    21.4200   -7.7700
            29  C8y C    20.2300   -7.0700
            30  C6a C    20.2300   -5.6700
            31  O6a O    19.0400   -4.9700
            32  O6a O    21.4200   -4.9700
            33  O1a O    22.6800   -7.0700
BOND        35
            1     5   1 1
            2     1   2 2
            3    10   7 1
            4     2   3 1
            5     3   4 2
            6     5   6 2
            7    10  11 1
            8     6   7 1
            9     7   8 1
            10    8   9 2
            11    9   5 1
            12    4   6 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  11 1
            19    9  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1
            32   29  30 1
            33   30  31 2
            34   30  32 1
            35   28  33 1

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