KEGG   DRUG: Dapiprazole
Entry
D07775                      Drug                                   

Name
Dapiprazole (INN)
Formula
C19H27N5
Exact mass
325.2266
Mol weight
325.4512
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
Remark
ATC code: S01EX02
Chemical structure group: DG01140
Product (DG01140): D03648<US>
Efficacy
Antiglaucoma, Neuroleptic, alpha-Adrenergic receptor antagonist
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX02 Dapiprazole
      D07775  Dapiprazole (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D07775  Dapiprazole (INN)
Other DBs
CAS: 72822-12-9
PubChem: 96024473
ChEBI: 51066
ChEMBL: CHEMBL1201216
DrugBank: DB00298
LigandBox: D07775
NIKKAJI: J111.116G
LinkDB
KCF data

ATOM        24
            1   C1x C    13.7900  -24.4300
            2   C1x C    13.7900  -25.8300
            3   C1x C    15.0024  -26.5300
            4   C8y C    16.2149  -25.8300
            5   N4y N    16.2149  -24.4300
            6   C1x C    15.0024  -23.7300
            7   N5x N    17.5464  -26.2626
            8   N5x N    18.3693  -25.1300
            9   C8y C    17.5464  -23.9974
            10  C1b C    17.9775  -22.6706
            11  C1b C    19.3569  -22.3774
            12  N1y N    20.3195  -23.4469
            13  C1x C    19.8840  -24.7868
            14  C1x C    20.8207  -25.8273
            15  N1y N    22.1901  -25.5364
            16  C1x C    22.6256  -24.1965
            17  C1x C    21.6889  -23.1560
            18  C8y C    23.1335  -26.5843
            19  C8x C    22.4035  -27.8144
            20  C8x C    23.0834  -29.0382
            21  C8x C    24.4832  -29.0613
            22  C8x C    25.2159  -27.8391
            23  C8y C    24.5360  -26.6153
            24  C1a C    25.2746  -25.3902
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 2
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   15  18 1
            21   18  19 2
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   18  23 1
            27   23  24 1

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