KEGG   DRUG: Dexamethasone phenylpropionate
Entry
D07801                      Drug                                   

Name
Dexamethasone phenylpropionate;
Dexafort [veterinary] (TN)
Formula
C31H37FO6
Exact mass
524.2574
Mol weight
524.6203
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07801  Dexamethasone phenylpropionate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07801  Dexamethasone phenylpropionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07801
Other DBs
CAS: 1879-72-7
PubChem: 96024498
LigandBox: D07801
NIKKAJI: J199.699A
LinkDB
KCF data

ATOM        38
            1   C2x C    18.4100  -23.8700
            2   C5x C    18.4100  -25.2000
            3   C2x C    19.6700  -25.9000
            4   C2y C    20.8600  -25.2000
            5   C1z C    20.8600  -23.8700
            6   C2x C    19.6700  -23.2400
            7   C1x C    21.9800  -25.9000
            8   C1x C    23.1700  -25.2000
            9   C1y C    23.1700  -23.8700
            10  C1z C    21.9800  -23.2400
            11  C1y C    24.3600  -23.2400
            12  C1z C    24.3600  -21.8400
            13  C1x C    23.1700  -21.2100
            14  C1y C    21.9800  -21.8400
            15  C1x C    26.7400  -23.2400
            16  C1y C    26.7400  -21.8400
            17  C1z C    25.5500  -21.2100
            18  O1a O    26.5300  -20.2300
            19  X   F    21.9800  -24.5000
            20  O5x O    17.2900  -25.9000
            21  C1a C    24.3600  -20.5100
            22  C1a C    20.8600  -22.5400
            23  O1a O    21.0700  -20.9300
            24  C1a C    28.1400  -21.2800
            25  C5a C    25.5500  -19.3900
            26  O5a O    24.3600  -18.6900
            27  C1b C    26.7400  -18.6900
            28  O7a O    27.9300  -19.3900
            29  C7a C    29.1900  -18.6900
            30  C1b C    30.3100  -19.3900
            31  O6a O    29.1900  -17.2900
            32  C1b C    31.5700  -18.6900
            33  C8y C    32.7600  -19.3900
            34  C8x C    32.7486  -20.7900
            35  C8x C    33.9553  -21.4998
            36  C8x C    35.1734  -20.8097
            37  C8x C    35.1148  -19.4097
            38  C8x C    33.9781  -18.6999
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1 #Down
            21   10  19 1 #Down
            22    2  20 2
            23   11  15 1
            24   12  21 1 #Up
            25    5  22 1 #Up
            26   14  23 1 #Up
            27   16  24 1 #Down
            28   25  26 2
            29   17  25 1 #Up
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   35  36 2
            40   36  37 1
            41   37  38 2
            42   33  38 1

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