KEGG   DRUG: Dexamethasone phosphate
Entry
D07802                      Drug                                   

Name
Dexamethasone phosphate;
Decadron-phosphate (TN)
Formula
C22H30FO8P
Exact mass
472.1662
Mol weight
472.441
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07802  Dexamethasone phosphate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07802  Dexamethasone phosphate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07802  Dexamethasone phosphate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07802  Dexamethasone phosphate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07802  Dexamethasone phosphate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07802  Dexamethasone phosphate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07802  Dexamethasone phosphate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07802  Dexamethasone phosphate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07802  Dexamethasone phosphate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07802  Dexamethasone phosphate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07802  Dexamethasone phosphate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07802  Dexamethasone phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07802
Other DBs
CAS: 312-93-6
PubChem: 96024499
ChEMBL: CHEMBL1201302 CHEMBL63694
PDB-CCD: 3T5[PDBj]
LigandBox: D07802
NIKKAJI: J5.658H
LinkDB
KCF data

ATOM        32
            1   C1y C    23.5200  -19.2500
            2   C1y C    22.3300  -19.9500
            3   C1z C    23.5200  -17.8500
            4   C1x C    25.9000  -19.2500
            5   C1z C    21.1400  -19.2500
            6   C1x C    22.3300  -21.2800
            7   C1z C    24.7100  -17.2200
            8   C1x C    22.3300  -17.2200
            9   C1a C    23.5200  -16.5200
            10  C1y C    25.9000  -17.9200
            11  C1z C    19.9500  -19.9500
            12  C1y C    21.1400  -17.8500
            13  X   F    21.1400  -20.5800
            14  C1x C    21.1400  -21.9800
            15  C5a C    24.7100  -15.8200
            16  O1a O    26.0400  -16.8000
            17  C1a C    27.2300  -17.7100
            18  C2y C    19.9500  -21.2800
            19  C2x C    18.7600  -19.2500
            20  C1a C    19.9500  -18.5500
            21  O1a O    19.9500  -17.1500
            22  C1b C    25.9000  -15.1200
            23  O5a O    23.5200  -15.1200
            24  C2x C    18.7600  -21.9800
            25  C2x C    17.5700  -19.9500
            26  O2b O    27.0900  -15.8200
            27  C5x C    17.5700  -21.2800
            28  P1b P    28.2100  -15.0500
            29  O5x O    16.3800  -21.9800
            30  O1c O    29.4000  -14.2800
            31  O1c O    27.4400  -13.8600
            32  O1c O    28.9100  -16.2624
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    5  13 1 #Down
            13    6  14 1
            14    7  15 1 #Up
            15    7  16 1 #Down
            16   10  17 1 #Down
            17   11  18 1
            18   11  19 1
            19   11  20 1 #Up
            20   12  21 1 #Up
            21   15  22 1
            22   15  23 2
            23   18  24 2
            24   19  25 2
            25   22  26 1
            26   24  27 1
            27   26  28 1
            28   27  29 2
            29   28  30 1
            30   28  31 1
            31    7  10 1
            32    8  12 1
            33   14  18 1
            34   25  27 1
            35   28  32 2

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