| Entry |
|
|---|
| Name |
Dorzolamide (INN);
Trusopt (TN) |
|---|
| Formula |
C10H16N2O4S3
|
|---|
| Exact mass |
324.0272
|
|---|
| Mol weight |
324.44
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01135): | D00653<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Carbonic anhydrase inhibitor |
|---|
| Comment |
Diuretic action
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04964 | Proximal tubule bicarbonate reclamation |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07055 | Sulfonamide derivatives - overview |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EC Carbonic anhydrase inhibitors
S01EC03 Dorzolamide
D07871 Dorzolamide (INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Lyases (EC4)
Aldehyde-lyases
CA
D07871 Dorzolamide (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07871
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 C8y C 19.3200 -14.9100
2 C8y C 19.3200 -16.3100
3 S2x S 20.5100 -14.2800
4 S2x S 17.9900 -14.4900
5 C1y C 20.5100 -17.0100
6 C8x C 17.9900 -16.7300
7 C1y C 21.7000 -14.9100
8 O3c O 19.2500 -13.3700
9 O3c O 21.6300 -13.4400
10 C8y C 17.2200 -15.6100
11 C1x C 21.7000 -16.3100
12 N1b N 20.5100 -18.4100
13 C1a C 22.8900 -14.2800
14 S4a S 15.8200 -15.6100
15 C1b C 21.7000 -19.0400
16 N1a N 15.8200 -17.2200
17 O3c O 15.8200 -14.2800
18 O3c O 14.3500 -15.6100
19 C1a C 21.7314 -20.4396
BOND 20
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 3 9 2
9 4 10 1
10 5 11 1
11 5 12 1 #Down
12 7 13 1 #Up
13 10 14 1
14 12 15 1
15 14 16 1
16 14 17 2
17 14 18 2
18 6 10 2
19 7 11 1
20 15 19 1
|
|---|
