KEGG   DRUG: Fendiline hydrochlorideHelp
Entry
D07943                      Drug                                   

Name
Fendiline hydrochloride;
Sensit (TN)
Formula
C23H25N. HCl
Exact mass
351.1754
Mol weight
351.9122
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01807  Phenylalkylamine derivative
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Remark
ATC code: C08EA01
Chemical structure group: DG00332
Efficacy
Vasodilator, Calcium channel blocker
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EA Phenylalkylamine derivatives
     C08EA01 Fendiline
      D07943  Fendiline hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D07943  Fendiline hydrochloride
BRITE hierarchy
Other DBs
CAS: 13636-18-5
PubChem: 96024638
ChEMBL: CHEMBL1405922
LigandBox: D07943
NIKKAJI: J280.744K
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C    18.7600  -18.9700
            2   C8x C    18.7600  -20.3700
            3   C8x C    19.9500  -21.0700
            4   C8x C    21.2100  -20.3700
            5   C8y C    21.2100  -18.9700
            6   C8x C    19.9500  -18.2700
            7   C1c C    22.4000  -18.2700
            8   C8y C    23.6600  -18.9700
            9   C8x C    23.6600  -20.3700
            10  C8x C    24.8500  -21.0700
            11  C8x C    26.0400  -20.3700
            12  C8x C    26.0400  -18.9700
            13  C8x C    24.8500  -18.2700
            14  C1b C    22.4000  -16.8700
            15  C1b C    23.6600  -16.1700
            16  N1b N    24.8500  -16.8700
            17  C1c C    26.0400  -16.1700
            18  C8y C    27.2300  -16.8700
            19  C1a C    26.0400  -14.7700
            20  C8x C    27.2300  -18.2700
            21  C8x C    28.4200  -18.9700
            22  C8x C    29.6100  -18.2700
            23  C8x C    29.6100  -16.8700
            24  C8x C    28.4200  -16.1700
            25  X   Cl   33.6000  -19.1100
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   18  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   18  24 1

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