KEGG   DRUG: Fludarabine
Entry
D07966                      Drug                                   
Name
Fludarabine (INN);
Fluradosa (TN)
Formula
C10H12FN5O4
Exact mass
285.0873
Mol weight
285.2318
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Same as: C21550
ATC code: L01BB05
Chemical structure group: DG00685
Product (DG00685): D01907<JP/US>
Efficacy
Antineoplastic, Antimetabolite
Comment
Arabinofuranosyl derivative
Target
RRM1 [HSA:6240] [KO:K10807]
DNA polymerase
RNA polymerase
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB05 Fludarabine
      D07966  Fludarabine (INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     DG00685  Fludarabine
      D07966  Fludarabine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM1
     D07966  Fludarabine (INN)
Prodrugs [br08324.html]
 D07966
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     DG00685  Fludarabine
Other DBs
CAS: 21679-14-1
PubChem: 96024661
LigandBox: D07966
NIKKAJI: J33.087F
LinkDB
KCF data

ATOM        20
            1   C1y C    23.1000  -18.6200
            2   C1y C    24.5000  -18.6200
            3   C1y C    24.9200  -17.2900
            4   O2x O    23.8000  -16.4500
            5   C1y C    22.6800  -17.2900
            6   O1a O    22.4000  -19.8100
            7   O1a O    25.2000  -19.8100
            8   N5x N    27.3000  -18.6900
            9   C8y C    27.3000  -17.2900
            10  N4y N    26.1100  -16.5900
            11  C1b C    21.4900  -16.5900
            12  C8y C    28.4900  -19.3900
            13  N5x N    29.7500  -18.6900
            14  C8y C    29.7500  -17.2900
            15  C8y C    28.4900  -16.5900
            16  N5x N    28.2100  -15.2600
            17  C8x C    26.8800  -15.1200
            18  N1a N    30.8700  -16.5900
            19  X   F    28.4900  -20.7900
            20  O1a O    20.2719  -17.2801
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Down
            7     2   7 1 #Up
            8     8   9 1
            9     9  10 1
            10    3  10 1 #Up
            11    5  11 1 #Up
            12    8  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16    9  15 2
            17   15  16 1
            18   16  17 2
            19   17  10 1
            20   14  18 1
            21   12  19 1
            22   11  20 1

» Japanese version   » Back

DBGET integrated database retrieval system