KEGG   DRUG: Levomethadone
Entry
D08121                      Drug                                   

Name
Levomethadone (INN)
Formula
C21H27NO
Exact mass
309.2093
Mol weight
309.4452
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
ATC code: N07BC05
Chemical structure group: DG01002
Efficacy
Analgesic, Opioid receptor agonist, NMDA receptor antagonist
Comment
Synthetic opioid
See Methadone [DR:D08195]
Target
OPRM1 [HSA:4988] [KO:K04215]
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07224  Opioid receptor agonists/antagonists
map07235  N-Methyl-D-aspartic acid (NMDA) receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC05 Levomethadone
      D08121  Levomethadone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08121  Levomethadone (INN)
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D08121  Levomethadone (INN)
Other DBs
CAS: 125-58-6
PubChem: 96024811
ChEMBL: CHEMBL159659
LigandBox: D08121
NIKKAJI: J56.319F
LinkDB
KCF data

ATOM        23
            1   C8x C    21.0000  -19.2500
            2   C8x C    21.0000  -20.6500
            3   C8x C    22.1900  -21.3500
            4   C8x C    23.3800  -20.6500
            5   C8y C    23.3800  -19.2500
            6   C8x C    22.1900  -18.6200
            7   C8x C    25.6900  -20.6500
            8   C8y C    25.6900  -19.2500
            9   C1d C    24.5000  -18.6200
            10  C8x C    26.8800  -21.3500
            11  C8x C    28.0700  -20.6500
            12  C8x C    28.0700  -19.2500
            13  C8x C    26.8800  -18.6200
            14  C1b C    24.5000  -17.2200
            15  C1c C    25.6900  -16.5200
            16  C5a C    22.5400  -17.5000
            17  N1c N    25.6900  -15.2600
            18  C1a C    26.8800  -14.5600
            19  C1a C    24.5000  -14.5600
            20  O5a O    22.5400  -16.1700
            21  C1b C    21.3500  -18.2000
            22  C1a C    20.2300  -17.5000
            23  C1a C    26.9053  -17.2151
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17    9  16 1
            18   15  17 1
            19   17  18 1
            20   17  19 1
            21   16  20 2
            22   16  21 1
            23   21  22 1
            24   15  23 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system