KEGG   DRUG: MometasoneHelp
Entry
D08227                      Drug                                   

Name
Mometasone (INN)
Formula
C22H28Cl2O4
Exact mass
426.1365
Mol weight
427.3613
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C07816
ATC code: D07AC13 D07XC03 R01AD09 R03BA07
Chemical structure group: DG00419
Product (DG00419): D00690<JP/US> D03325<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC13 Mometasone
      D08227  Mometasone (INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC03 Mometasone
      D08227  Mometasone (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD09 Mometasone
      D08227  Mometasone (INN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA07 Mometasone
      D08227  Mometasone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D08227  Mometasone (INN)
BRITE hierarchy
Other DBs
CAS: 105102-22-5
PubChem: 96024915
ChEBI: 6970
ChEMBL: CHEMBL1201404
DrugBank: DB00764
LigandBox: D08227
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1z C    23.5200  -18.7600
            2   C1y C    24.7100  -19.3900
            3   C1z C    22.3300  -19.3900
            4   C1y C    23.5200  -17.3600
            5   X   Cl   23.5200  -20.0900
            6   C1y C    25.9000  -18.7600
            7   C1x C    24.7100  -20.7900
            8   C2y C    22.3300  -20.7900
            9   C2x C    21.1400  -18.7600
            10  C1a C    22.3300  -18.0600
            11  C1x C    24.7100  -16.7300
            12  O1a O    22.3300  -16.6600
            13  C1z C    25.9000  -17.3600
            14  C1x C    28.2100  -18.7600
            15  C1x C    23.5200  -21.4900
            16  C2x C    21.1400  -21.4900
            17  C2x C    20.0200  -19.3900
            18  C1z C    27.0200  -16.7300
            19  C1a C    25.9000  -16.0300
            20  C1y C    28.2100  -17.3600
            21  C5x C    20.0200  -20.7900
            22  C5a C    27.0200  -15.1200
            23  O1a O    28.2100  -16.0300
            24  C1a C    29.5400  -16.9400
            25  O5x O    18.8300  -21.4200
            26  C1b C    28.2100  -14.4200
            27  O5a O    25.8300  -14.4200
            28  X   Cl   29.4000  -15.1200
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     3  10 1 #Up
            10    4  11 1
            11    4  12 1 #Up
            12    6  13 1
            13    6  14 1
            14    7  15 1
            15    8  16 2
            16    9  17 2
            17   13  18 1
            18   13  19 1 #Up
            19   14  20 1
            20   16  21 1
            21   18  22 1 #Up
            22   18  23 1 #Down
            23   20  24 1 #Down
            24   21  25 2
            25   22  26 1
            26   22  27 2
            27   26  28 1
            28    8  15 1
            29   11  13 1
            30   17  21 1
            31   18  20 1

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