KEGG   DRUG: Morphine tartrate
Entry
D08234                      Drug                                   

Name
Morphine tartrate;
Morphine Tartrate (TN)
Formula
(C17H19NO3)2. C4H6O6
Exact mass
720.2894
Mol weight
720.7622
Structure
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
ATC code: N02AA01
Chemical structure group: DG00810
Product (DG00810): D00842<JP/US> D02271<JP>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Other map
map05032  Morphine addiction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA01 Morphine
      D08234  Morphine tartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08234  Morphine tartrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08234
Other DBs
CAS: 302-31-8
PubChem: 96024922
LigandBox: D08234
LinkDB
KCF data

ATOM        52
            1   C1z C    17.5000  -23.2400
            2   C8y C    17.5000  -21.9100
            3   C1y C    18.6900  -23.9400
            4   C1y C    16.3800  -23.8700
            5   C1x C    18.6900  -22.5400
            6   C8y C    16.3800  -21.2800
            7   C8y C    18.6900  -21.2800
            8   C1y C    19.7400  -23.2400
            9   C2x C    18.6900  -25.2000
            10  O2x O    15.0500  -22.4700
            11  C1y C    16.3800  -25.2000
            12  C1x C    20.8600  -22.5400
            13  C8y C    16.3800  -19.9500
            14  C1x C    19.7400  -21.9800
            15  C8x C    18.6900  -19.9500
            16  N1y N    20.8600  -23.9400
            17  C2x C    17.5000  -25.9000
            18  O1a O    15.2600  -25.9000
            19  C8x C    17.5700  -19.3200
            20  O1a O    15.2600  -19.3200
            21  C1a C    22.2600  -23.9400
            22  O6a O    26.4600  -22.4700
            23  C6a C    27.6724  -21.7700
            24  C1c C    28.8849  -22.4700
            25  C1c C    30.0973  -21.7700
            26  C6a C    31.3097  -22.4700
            27  O6a O    32.5222  -21.7700
            28  O6a O    27.6724  -20.3702
            29  O6a O    31.3097  -23.8699
            30  O1a O    28.8849  -23.8698
            31  O1a O    30.0973  -20.3700
            32  C1z C    17.5000  -23.2400
            33  C8y C    17.5000  -21.9100
            34  C8y C    16.3800  -21.2800
            35  C8y C    16.3800  -19.9500
            36  C8x C    17.5700  -19.3200
            37  C8x C    18.6900  -19.9500
            38  C8y C    18.6900  -21.2800
            39  C1x C    19.7400  -21.9800
            40  C1y C    19.7400  -23.2400
            41  C1y C    18.6900  -23.9400
            42  C2x C    18.6900  -25.2000
            43  C2x C    17.5000  -25.9000
            44  C1y C    16.3800  -25.2000
            45  C1y C    16.3800  -23.8700
            46  O2x O    15.0500  -22.4700
            47  O1a O    15.2600  -25.9000
            48  N1y N    20.8600  -23.9400
            49  C1x C    20.8600  -22.5400
            50  C1x C    18.6900  -22.5400
            51  C1a C    22.2600  -23.9400
            52  O1a O    15.2600  -19.3200
BOND        59
            1    22  23 1
            2    23  24 1
            3    24  25 1
            4    25  26 1
            5    26  27 1
            6    23  28 2
            7    26  29 2
            8    24  30 1 #Up
            9    25  31 1 #Up
            10    1   2 1
            11    1   3 1
            12    1   4 1
            13    1   5 1 #Up
            14    2   6 2
            15    2   7 1
            16    3   8 1
            17    3   9 1
            18    4  10 1 #Down
            19    4  11 1
            20    5  12 1
            21    6  13 1
            22    7  14 1
            23    7  15 2
            24    8  16 1 #Up
            25    9  17 2
            26   11  18 1 #Down
            27   13  19 2
            28   13  20 1
            29    6  10 1
            30    8  14 1
            31   11  17 1
            32   12  16 1
            33   15  19 1
            34   16  21 1
            35   32  33 1
            36   32  41 1
            37   32  45 1
            38   32  50 1 #Up
            39   33  34 2
            40   33  38 1
            41   41  40 1
            42   41  42 1
            43   45  46 1 #Down
            44   45  44 1
            45   50  49 1
            46   34  35 1
            47   38  39 1
            48   38  37 2
            49   40  48 1 #Up
            50   42  43 2
            51   44  47 1 #Down
            52   35  36 2
            53   35  52 1
            54   34  46 1
            55   40  39 1
            56   44  43 1
            57   49  48 1
            58   37  36 1
            59   48  51 1
BRACKET     1    13.2300  -28.0000   13.2300  -17.7800
            1    24.2900  -17.7800   24.2900  -28.0000
            1  2
 ORIGINAL  1    1   2   6  13  19  15   7  14   8   3   9  17  11   4  10  18
            1   21  16  12   5  22  20
 REPEAT    1   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            1   49  50  51  52  53  54

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