KEGG   DRUG: Norfloxacin nicotinate
Entry
D08287                      Drug                                   

Name
Norfloxacin nicotinate;
Quinabic soluble powder (TN) [veterinary]
Formula
C16H18FN3O3. C6H5NO2
Exact mass
442.1652
Mol weight
442.4402
Structure
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG02852  CYP3A inhibitor
Remark
ATC code: J01MA06 S01AE02
Chemical structure group: DG00620
Product (DG00620): D00210<JP>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA06 Norfloxacin
      D08287  Norfloxacin nicotinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE02 Norfloxacin
      D08287  Norfloxacin nicotinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08287
Other DBs
CAS: 118803-81-9
PubChem: 96024974
LigandBox: D08287
LinkDB
KCF data

ATOM        32
            1   C8y C    24.7100  -18.2700
            2   C8y C    24.7100  -16.8700
            3   N4y N    25.9700  -18.9700
            4   C8x C    23.5200  -18.9700
            5   C8y C    25.9700  -16.1700
            6   C8x C    23.5200  -16.1700
            7   C8x C    27.1600  -18.2700
            8   C1b C    25.9700  -20.3700
            9   C8y C    22.2600  -18.2700
            10  C8y C    27.1600  -16.8700
            11  O5x O    25.9700  -14.7700
            12  C8y C    22.2600  -16.8700
            13  C1a C    24.7100  -21.0700
            14  N1y N    21.0700  -18.9700
            15  C6a C    28.4200  -16.1700
            16  X   F    21.0700  -16.2400
            17  C1x C    19.8800  -18.2700
            18  C1x C    21.0700  -20.3700
            19  O6a O    29.6100  -16.8700
            20  O6a O    28.4200  -14.7700
            21  C1x C    18.6900  -18.9700
            22  C1x C    19.8800  -21.0700
            23  N1x N    18.6900  -20.3700
            24  C8x C    32.6200  -17.2900
            25  C8x C    32.6200  -18.6900
            26  N5x N    33.8324  -19.3900
            27  C8x C    35.0449  -18.6900
            28  C8y C    35.0449  -17.2900
            29  C8x C    33.8324  -16.5900
            30  C6a C    36.2760  -16.5790
            31  O6a O    37.4812  -17.2747
            32  O6a O    36.2757  -15.1901
BOND        34
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1
            32   28  30 1
            33   30  31 1
            34   30  32 2

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