KEGG   DRUG: Proligestone
Entry
D08429                      Drug                                   

Name
Proligestone (INN);
Covinan [veterinary] (TN);
Delvosteron [veterinary] (TN)
Formula
C24H34O4
Exact mass
386.2457
Mol weight
386.5244
Structure
Simcomp
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Efficacy
Estrus suppressant (veterinary)
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D08429  Proligestone (INN)
    NR3C3 (PGR)
     D08429  Proligestone (INN)
Animal drugs in Japan [BR:br08331]
 94  Agents for breeding
  941  Hormone preparations (except posterior-pituitary hormone and preparations)
   9415  Luteinizing hormone and preparations
    D08429  Proligestone (INN)
Other DBs
CAS: 23873-85-0
PubChem: 96025115
ChEMBL: CHEMBL2106696
LigandBox: D08429
NIKKAJI: J15.818F
LinkDB
KCF data

ATOM        28
            1   C1x C    19.3900  -27.4400
            2   C5x C    19.3900  -28.8400
            3   C2x C    20.6024  -29.5400
            4   C2y C    21.8149  -28.8400
            5   C1z C    21.8149  -27.4400
            6   C1x C    20.6024  -26.7400
            7   C1x C    23.0273  -29.5400
            8   C1x C    24.2397  -28.8400
            9   C1y C    24.2397  -27.4400
            10  C1y C    23.0273  -26.7400
            11  C1z C    25.4522  -26.7400
            12  C1z C    25.4522  -25.3400
            13  C1x C    24.2397  -24.6400
            14  C1x C    23.0273  -25.3400
            15  O2x O    26.6646  -27.4400
            16  C1y C    27.8770  -26.7400
            17  O2x O    27.8770  -25.3400
            18  C1z C    26.6646  -24.6400
            19  O5x O    18.1776  -29.5400
            20  C1a C    21.8149  -26.0402
            21  C1a C    25.4522  -23.9403
            22  C5a C    26.6646  -23.2400
            23  C1a C    27.8811  -22.5377
            24  O5a O    25.4562  -22.5423
            25  C1x C    26.7346  -26.6700
            26  C1x C    27.0846  -25.6900
            27  C1b C    29.0766  -27.4327
            28  C1a C    30.2659  -26.7460
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   12  18 1
            22    2  19 2
            23    5  20 1 #Up
            24   12  21 1 #Up
            25   18  22 1
            26   22  23 1
            27   22  24 2
            28   11  25 1 #Up
            29   18  26 1 #Up
            30   25  26 1
            31   16  27 1
            32   27  28 1

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