| Entry |
|
|---|
| Name |
Propranolol (INN);
Propranolol (TN) |
|---|
| Formula |
C16H21NO2
|
|---|
| Exact mass |
259.1572
|
|---|
| Mol weight |
259.3434
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00305): | D00483<JP/US> |
|
|---|
| Efficacy |
Antiarrhythmic, Antihypertensive, beta-Adrenergic receptor antagonist |
|---|
| Comment |
Class II antiarrhythmic agent
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP1A2 [HSA: 1544], CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA05 Propranolol
D08443 Propranolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00305 Propranolol
D08443 Propranolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00305 Propranolol
D08443 Propranolol
DG03231 Antihypertensive
DG00305 Propranolol
D08443 Propranolol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00305 Propranolol
D08443 Propranolol
DG01639 CYP2C19 substrate
DG00305 Propranolol
D08443 Propranolol
DG01644 CYP2D6 substrate
DG00305 Propranolol
D08443 Propranolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D08443 Propranolol (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08443
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00305 Propranolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00305 Propranolol
DG03231 Antihypertensive
DG00305 Propranolol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00305 Propranolol
DG01639 CYP2C19 substrate
DG00305 Propranolol
DG01644 CYP2D6 substrate
DG00305 Propranolol
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 C8y C 21.0700 -18.9700
2 C8y C 22.3300 -18.2700
3 C8y C 21.0700 -20.3700
4 C8x C 19.8800 -18.2700
5 O2a O 22.3300 -16.8700
6 C8x C 23.5200 -18.9700
7 C8x C 22.2600 -21.0700
8 C8x C 19.8800 -21.0700
9 C8x C 18.6900 -18.9700
10 C1b C 23.5200 -16.1700
11 C8x C 23.5200 -20.3700
12 C8x C 18.6900 -20.3700
13 C1c C 24.7100 -16.8700
14 C1b C 25.9700 -16.1700
15 O1a O 24.7100 -18.2700
16 N1b N 27.1600 -16.8700
17 C1c C 28.3500 -16.1700
18 C1a C 29.6100 -16.8700
19 C1a C 28.3500 -14.7700
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 6 11 1
11 8 12 2
12 10 13 1
13 13 14 1
14 13 15 1
15 14 16 1
16 16 17 1
17 17 18 1
18 17 19 1
19 7 11 2
20 9 12 1
|
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