KEGG   DRUG: Amoxicillin hydrate, clarithromycin and lansoprazole
Entry
D08774            Mixture   Drug                                   

Name
Amoxicillin hydrate, clarithromycin and lansoprazole;
Lansap (TN);
Prevpac (TN)
Product
  Generic
Component
Amoxicillin hydrate [DR:D00229], Clarithromycin [DR:D00276], Lansoprazole [DR:D00355]
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: A02BD07 J01RA01
Product: D08774<US>
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Lansoprazole is primarily metabolized by CYP2C19 and CYP3A4.
Clarithromycin is an inhibitor and a substrate of CYP3A4, and it is an inhibitor of P-gp.
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD07 Lansoprazole, amoxicillin and clarithromycin
      D08774  Amoxicillin hydrate, clarithromycin and lansoprazole <US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01R COMBINATIONS OF ANTIBACTERIALS
    J01RA Combinations of antibacterials
     J01RA01 Penicillins, combinations with other antibacterials
      D08774  Amoxicillin hydrate, clarithromycin and lansoprazole <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Lansoprazole/ Amoxicillin/ Clarithromycin
    D08774  Amoxicillin hydrate, clarithromycin and lansoprazole
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08774
 Drug transporters
  D08774
Other DBs
PubChem: 96025457
LinkDB

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