KEGG   DRUG: Antithrombin alfa
Entry
D08858                      Drug                                   
Name
Antithrombin alfa (INN/USAN);
Atryn (TN)
Formula
C2191H3451N583O656S18
Exact mass
49001.9576
Mol weight
49032.56
Sequence
HGSPVDICTA KPRDIPMNPM CIYRSPEKKA TEDEGSEQKI PEATNRRVWE LSKANSRFAT
TFYQHLADSK NDNDNIFLSP LSISTAFAMT KLGACNDTLQ QLMEVFKFDT ISEKTSDQIH
FFFAKLNCRL YRKANKSSKL VSANRLFGDK SLTFNETYQD ISELVYGAKL QPLDFKENAE
QSRAAINKWV SNKTEGRITD VIPSEAINEL TVLVLVNTIY FKGLWKSKFS PENTRKELFY
KADGESCSAS MMYQEGKFRY RRVAEGTQVL ELPFKGDDIT MVLILPKPEK SLAKVEKELT
PEVLQEWLDE LEEMMLVVHM PRFRIEDGFS LKEQLQDMGL VDLFSPEKSK LPGIVAEGRD
DLYVSDAFHK AFLEVNEEGS EAAASTAVVI AGRSLNPNRV TFKANRPFLV FIREVPLNTI
IFMGRVANPC VK
(Disulfide bridge: 8-128, 21-95, 247-430; Glycosylation site: 95, 135, 155, 192)
  Type
Peptide
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
   DG03285  Antithrombin
Remark
ATC code: B01AB02
Efficacy
Anticoagulant
  Disease
Hereditary antithrombin deficiency [DS:H01381]
Comment
Recombinant human antithrombin [HSA:462] [KO:K03911]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AB Heparin group
     B01AB02 Antithrombin III
      D08858  Antithrombin alfa (INN/USAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01709  Heparin anticoagulant
    DG03285  Antithrombin
     D08858  Antithrombin alfa
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08858
Other DBs
CAS: 84720-88-7
PubChem: 96025541
LinkDB

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