KEGG   DRUG: Choline fenofibrateHelp
Entry
D08890                      Drug                                   

Name
Choline fenofibrate (USAN/INN);
Trilipix (TN)
Product
  Generic
Formula
C17H14ClO4. C5H14NO
Exact mass
421.1656
Mol weight
421.9144
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01946  Hypolipidemic agent
  DG01547  Fibrates
Other
 DG01733  PPAR agonist
  DG01547  Fibrates
Remark
ATC code: C10AB11
Chemical structure group: DG01548
Product (DG01548): D00565<JP/US> D08890<US>
Efficacy
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
  Disease
Hypertriglyceridemia [DS:H01637]
Primary hypercholesterolemia or mixed dyslipidemia [DS:H01635]
Comment
Clofibrate derivative
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB11 Choline fenofibrate
      D08890  Choline fenofibrate (USAN/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Choline Fenofibrate
    D08890  Choline fenofibrate (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D08890  Choline fenofibrate (USAN/INN) <US>
BRITE hierarchy
Other DBs
CAS: 856676-23-8
PubChem: 96025573
ChEMBL: CHEMBL1201745
LigandBox: D08890
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8y C    18.3598  -16.7433
            2   C5a C    17.1689  -17.4439
            3   C8x C    19.6208  -17.4439
            4   C8x C    18.3598  -15.3422
            5   C8y C    15.9779  -16.7433
            6   O5a O    17.1689  -18.8450
            7   C8x C    20.8118  -16.7433
            8   C8x C    19.6208  -14.6417
            9   C8x C    14.7169  -17.4439
            10  C8x C    15.9779  -15.3422
            11  C8y C    20.8118  -15.3422
            12  C8x C    13.5260  -16.7433
            13  C8x C    14.7169  -14.6417
            14  O2a O    22.0027  -14.6417
            15  C8y C    13.5260  -15.3422
            16  C1d C    23.2637  -15.3422
            17  X   Cl   12.3350  -14.6417
            18  C6a C    24.4547  -14.6417
            19  O6a O    25.6456  -15.3422 #-
            20  O6a O    24.4547  -13.2406
            21  C1a C    22.5632  -16.5332
            22  C1a C    23.9643  -16.5332
            23  C1a C    29.8900  -16.7300
            24  N1d N    31.0800  -16.0300 #+
            25  C1b C    32.3400  -16.7300
            26  C1b C    33.5300  -16.0300
            27  O1a O    34.7200  -16.7300
            28  C1a C    31.0800  -14.6300
            29  C1a C    31.0800  -17.4300
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   18  20 2
            20    8  11 1
            21   13  15 1
            22   16  21 1
            23   16  22 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   24  28 1
            29   24  29 1

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