KEGG   DRUG: Gabapentin enacarbil
Entry
D09539                      Drug                                   

Name
Gabapentin enacarbil (JAN/USAN/INN);
Horizant (TN)
Product
Formula
C16H27NO6
Exact mass
329.1838
Mol weight
329.3887
Structure
Class
Neuropsychiatric agent
 DG02037  GABA mimetic antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01574  Calcium channel alpha-2 delta blocker
Remark
Therapeutic category: 1190
ATC code: N03AX12
Chemical structure group: DG01245
Product (DG01245): D00332<JP/US> D09539<JP/US>
Efficacy
Anticonvulsant
  Disease
Restless legs syndrome [DS:H01597]
Postherpetic neuralgia [DS:H01624]
Comment
Active form of prodrug: Gabapentin [DR:D00332]
Target
CACNA2D [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861]
SLC6A1 (GAT1) [HSA:6529] [KO:K05034]
  Pathway
hsa04010  MAPK signaling pathway
hsa04727  GABAergic synapse
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX12 Gabapentin
      D09539  Gabapentin enacarbil (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   GABA Agents, Other
    Gabapentin
     D09539  Gabapentin enacarbil (JAN/USAN/INN)
 Central Nervous System Agents
  Central Nervous System, Other
   Gabapentin
    D09539  Gabapentin enacarbil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D09539  Gabapentin enacarbil (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA2D
     D09539  Gabapentin enacarbil (JAN/USAN/INN) <JP/US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A1 (GAT1)
     D09539  Gabapentin enacarbil (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09539
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09539
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09539
Prodrugs [br08324.html]
 D09539
Other DBs
PubChem: 96026219
ChEMBL: CHEMBL1628502
LigandBox: D09539
LinkDB
KCF data

ATOM        23
            1   C1x C    17.3600  -19.4600
            2   C1x C    17.3600  -20.8600
            3   C1z C    18.5500  -21.5600
            4   C1x C    19.8100  -20.8600
            5   C1x C    19.8100  -19.4600
            6   C1x C    18.5500  -18.7600
            7   N1b N    16.1700  -21.5600
            8   C1b C    17.3600  -22.2600
            9   C1b C    19.7400  -22.2600
            10  C6a C    20.9300  -21.5600
            11  O6a O    20.9300  -20.1600
            12  O6a O    22.1453  -22.2551
            13  C7a C    14.9576  -22.2600
            14  O7a O    13.7451  -21.5600
            15  C1c C    12.5327  -22.2600
            16  O7a O    11.3203  -21.5600
            17  C7a C    10.1078  -22.2600
            18  C1c C     8.8954  -21.5600
            19  C1a C     7.6830  -22.2600
            20  O6a O    14.9576  -23.6598
            21  C1a C    12.5327  -23.6600
            22  O6a O    10.1078  -23.6597
            23  C1a C     8.8954  -20.1600
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   3 1
            9     3   9 1
            10    9  10 1
            11   10  11 2
            12   10  12 1
            13    7  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   13  20 2
            21   15  21 1
            22   17  22 2
            23   18  23 1

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