KEGG   DRUG: IntetumumabHelp
Entry
D09631                      Drug                                   

Name
Intetumumab (USAN/INN)
Formula
C6468H10008N1744O2006S40
Exact mass
145488.3555
Mol weight
145577.7523
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSRRL SCAASGFTFS RYTMHWVRQA PGKGLEWVAV ISFDGSNKYY
VDSVKGRFTI SRDNSENTLY LQVNILRAED TAVYYCAREA RGSYAFDIWG QGTMVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPPFTFG PGTKVDIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H146-H202, H263-H323, H369-H427, H228-H'228, H231-H'231, L23-L88, L135-L195, H222-L215)
  Type
Peptide
Efficacy
Antineoplastic, Angiogenesis inhibitor
Comment
Monoclonal antibody
Treatment of solid tumors
Target
ITGAV (CD51) [HSA:3685] [KO:K06487]
  Pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecules (CAMs)
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: other families
   Integrins
    ITGAV (CD51)
     D09631  Intetumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 725735-28-4
PubChem: 124490371
LinkDB All DBs

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