KEGG   DRUG: RontalizumabHelp
Entry
D09662                      Drug                                   

Name
Rontalizumab (USAN/INN)
Formula
C6486H9990N1722O2026S44
Exact mass
145825.9336
Mol weight
145915.9026
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCATSGYTFT EYIIHWVRQA PGKGLEWVAS INPDYDITNY
NQRFKGRFTI SLDKSKRTAY LQMNSLRAED TAVYYCASWI SDFFDYWGQG TLVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSVS TSSYSYMHWY QQKPGKAPKV LISYASNLES
GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQHSWGIPR TFGQGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H144-H200, H261-H321, H367-H425, H226-H'226, H229-H'229, L23-L92, L138-L198, H220-L218)
  Type
Peptide
Efficacy
Immunosuppressant, Anti-IFN-alpha antibody
Comment
Monoclonal antibody
Treatment of systemic lupus erythematosus (SLE)
Target
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interferons
    IFNA
     D09662  Rontalizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 948570-30-7
PubChem: 124490402
LinkDB All DBs

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