KEGG   DRUG: Tafamidis meglumine
Entry
D09674                      Drug                                   
Name
Tafamidis meglumine (JAN/USAN);
Vyndaqel (TN)
Product
TAFAMIDIS MEGLUMINE (Pfizer Laboratories Div Pfizer)
Formula
C14H7Cl2NO3. C7H17NO5
Exact mass
502.091
Mol weight
503.3299
Structure
Remark
Therapeutic category: 1290 2190
ATC code: N07XX08
Chemical structure group: DG01009
Product (DG01009): D09673<JP> D09674<JP/US>
Efficacy
Amyloidogenesis suppressant
  Disease
Hereditary transthyretin-mediated amyloidosis [DS:H00845]
Comment
Tafamidis stabilizes tetrameric form of the transthyretin [HSA:7276]
Treatment of transthyretin-associated amyloidosis
Target
TTR [HSA:7276] [KO:K20731]
  Pathway
hsa04918  Thyroid hormone synthesis
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX08 Tafamidis
      D09674  Tafamidis meglumine (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Tafamidis
   D09674  Tafamidis meglumine (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   129  Miscellaneous
    1290  Miscellaneous
     D09674  Tafamidis meglumine (JAN/USAN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D09674  Tafamidis meglumine (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Others
    TTR
     D09674  Tafamidis meglumine (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09674
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09674
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09674
Other DBs
CAS: 951395-08-7
PubChem: 124490414
ChEBI: 79345
LigandBox: D09674
LinkDB
KCF data

ATOM        33
            1   C8y C    12.3900  -25.9000
            2   C8y C    12.3900  -27.3000
            3   C8x C    13.6500  -28.0000
            4   C8x C    14.8400  -27.3000
            5   C8y C    14.8400  -25.9000
            6   C8x C    13.6500  -25.2000
            7   O2x O    11.0600  -25.4800
            8   C8y C    10.2200  -26.6000
            9   N5x N    11.0600  -27.7200
            10  C8y C     8.8200  -26.6000
            11  C6a C    16.0300  -25.2000
            12  O6a O    17.2900  -25.9000
            13  O6a O    16.0300  -23.8000
            14  C8x C     8.1200  -25.4100
            15  C8y C     6.7200  -25.4100
            16  C8x C     6.0200  -26.6000
            17  C8y C     6.7200  -27.8600
            18  C8x C     8.1200  -27.8600
            19  X   Cl    6.0200  -24.2200
            20  X   Cl    6.0200  -29.0500
            21  C1a C    20.5800  -26.8800
            22  N1b N    21.7924  -26.1800
            23  C1b C    23.0049  -26.8800
            24  C1c C    24.2173  -26.1800
            25  C1c C    25.4297  -26.8800
            26  C1c C    26.6422  -26.1800
            27  C1c C    27.8546  -26.8800
            28  C1b C    29.0670  -26.1800
            29  O1a O    30.2795  -26.8800
            30  O1a O    24.2173  -24.7800
            31  O1a O    25.4297  -28.2799
            32  O1a O    26.6422  -24.7803
            33  O1a O    27.8546  -28.2800
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 2
            10    2   9 1
            11    8  10 1
            12    5  11 1
            13   11  12 1
            14   11  13 2
            15   10  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   10  18 2
            21   15  19 1
            22   17  20 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   24  30 1 #Down
            32   25  31 1 #Down
            33   26  32 1 #Down
            34   27  33 1 #Up

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