KEGG   DRUG: Pioglitazone hydrochloride and glimepiride tablets
Entry
D09848            Mixture   Drug                                   

Name
Pioglitazone hydrochloride and glimepiride tablets (JP17);
Pioglitazone and glimepiride;
Duetact;
Sonias (TN)
Product
  Generic
Component
(Pioglitazone hydrochloride [DR:D00945] | Pioglitazone [DR:D08378]), Glimepiride [DR:D00593]
Class
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 3969
ATC code: A10BD06
Product: D09848<JP/US>
Efficacy
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Pioglitazone is primarily metabolized by CYP2C8.
Glimepiride is primarily metabolized by CYP2C9.
Metabolism
Enzyme: CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BD Combinations of oral blood glucose lowering drugs
     A10BD06 Glimepiride and pioglitazone
      D09848  Pioglitazone hydrochloride and glimepiride tablets (JP17) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Combinations
   Pioglitazone Hydrochloride/ Glimepiride
    D09848  Pioglitazone hydrochloride and glimepiride tablets (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D09848  Pioglitazone hydrochloride and glimepiride tablets (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D09848  Pioglitazone hydrochloride and glimepiride tablets
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09848
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09848
Other DBs
PubChem: 124490587
LinkDB

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