KEGG   DRUG: Etrolizumab
Entry
D09901                      Drug                                   

Name
Etrolizumab (USAN/INN)
Formula
C6396H9874N1702O2010S42
Exact mass
144029.1017
Mol weight
144117.7642
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFFIT NNYWGWVRQA PGKGLEWVGY ISYSGSTSYN
PSLKSRFTIS RDTSKNTFYL QMNSLRAEDT AVYYCARTGS SGYFDFWGQG TLVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASESVD DLLHWYQQKP GKAPKLLIKY ASQSISGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GNSLPNTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H144-H200, H261-H321, H367-H425, H226-H'226, H229-H'229, L23-L88, L134-L194, H220-L214)
  Type
Peptide
Efficacy
Anti-inflammatory
Comment
Monoclonal antibody
Treatment of inflammatory bowel disease
Target
ITGB7 [HSA:3695] [KO:K06590]
  Pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: other families
   Integrins
    ITGB7
     D09901  Etrolizumab (USAN/INN)
Other DBs
CAS: 1044758-60-2
PubChem: 124490613
LinkDB

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