KEGG   DRUG: Hemin
Entry
D10003                      Drug                                   
Name
Hemin (JAN);
Normosang (TN);
Panhematin (TN)
Product
Formula
C34H30ClFeN4O4. 2H
Exact mass
651.1461
Mol weight
651.94
Structure
Simcomp
Class
Metabolizing enzyme inducer
 DG01938  CYP2D6 inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
Therapeutic category: 6349
ATC code: B06AB01
Product: D10003<JP/US>
Efficacy
Accumulation reduction (porphyrin precursor), ALAS activity lowering agent
  Disease
Acute intermittent porphyria [DS:H01763]
Comment
See [CPD:C06767]
Target
ALAS [HSA:211 212] [KO:K00643]
  Pathway
hsa00860  Porphyrin metabolism
Interaction
CYP induction: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AB Heme products
     B06AB01 Hemin
      D10003  Hemin (JAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6349  Others
     D10003  Hemin (JAN)
Drug groups [BR:br08330]
 Metabolizing enzyme inducer
  DG01938  CYP2D6 inducer
   D10003  Hemin
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    D10003  Hemin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Acyltransferases
    ALAS
     D10003  Hemin (JAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10003
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10003
Other DBs
CAS: 16009-13-5
PubChem: 135626724
LinkDB
KCF data

ATOM        44
            1   Z   Fe   24.7961  -17.8832
            2   X   Cl   24.7961  -15.9409
            3   C8y C    25.9742  -14.7896
            4   N5x N    25.9742  -16.5309
            5   C8y C    27.2467  -16.5309
            6   C8y C    28.0504  -15.4593
            7   C8y C    27.2467  -14.3878
            8   C8x C    24.8356  -14.1198
            9   C8y C    23.6301  -14.7896
            10  N4y N    23.6301  -16.5309
            11  C8y C    22.3575  -14.3878
            12  C8y C    21.6208  -15.4593
            13  C8y C    22.3575  -16.5309
            14  C8x C    21.7548  -17.7365
            15  C8y C    22.4246  -18.8751
            16  C8y C    27.2467  -18.8751
            17  C8x C    27.9164  -17.7365
            18  N4y N    26.0412  -18.8751
            19  C8y C    26.0412  -20.6163
            20  C8y C    27.3136  -21.0181
            21  C8y C    28.1173  -19.9466
            22  N5x N    23.6971  -18.8751
            23  C8y C    23.6971  -20.6163
            24  C8x C    24.9026  -21.2861
            25  C8y C    21.6878  -19.9466
            26  C8y C    22.4246  -21.0181
            27  C1a C    20.2814  -15.4593
            28  C1a C    20.3483  -19.9466
            29  C1a C    29.4565  -19.9206
            30  C2b C    29.3899  -15.4593
            31  C2a C    30.0596  -16.6193
            32  C2b C    22.3575  -13.0483
            33  C2a C    23.5176  -12.3785
            34  C1a C    27.2467  -13.0483
            35  C1b C    22.4246  -22.3576
            36  C1b C    27.3136  -22.3576
            37  C1b C    21.2645  -23.0275
            38  C6a C    21.2644  -24.3667
            39  O6a O    20.1205  -25.0272
            40  O6a O    22.4406  -25.0459 #-
            41  C1b C    28.4737  -23.0275
            42  C6a C    28.4738  -24.3667
            43  O6a O    29.6177  -25.0272 #-
            44  O6a O    27.2976  -25.0459
BOND        49
            1     1   2 1
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     3   7 1
            7     3   8 2
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11   11  12 1
            12   12  13 2
            13   10  13 1
            14   13  14 1
            15   14  15 2
            16   16  17 2
            17    5  17 1
            18   18  19 1
            19   19  20 1
            20   20  21 2
            21   21  16 1
            22   18  16 1
            23   22  23 2
            24   23  24 1
            25   19  24 2
            26   22  15 1
            27   15  25 1
            28   25  26 2
            29   23  26 1
            30   12  27 1
            31   25  28 1
            32   21  29 1
            33    6  30 1
            34   30  31 2
            35   11  32 1
            36   32  33 2
            37    7  34 1
            38   26  35 1
            39   20  36 1
            40   35  37 1
            41   37  38 1
            42   38  39 2
            43   38  40 1
            44   36  41 1
            45   41  42 1
            46   42  43 1
            47   42  44 2
            48    1  10 1
            49    1  18 1

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