KEGG   DRUG: Metformin hydrochloride and saxagliptin hydrochloride
Entry
D10263            Mixture   Drug                                   

Name
Metformin hydrochloride and saxagliptin hydrochloride;
Kombiglyze (TN)
Product
Component
Metformin hydrochloride [DR:D00944], (Saxagliptin [DR:D08996] | Saxagliptin hydrochloride [DR:D10262])
Remark
ATC code: A10BD10
Product: D10263<US>
Efficacy
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
The metabolism of saxagliptin is primarily mediated by cytochrome P450 3A4/5.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BD Combinations of oral blood glucose lowering drugs
     A10BD10 Metformin and saxagliptin
      D10263  Metformin hydrochloride and saxagliptin hydrochloride <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Combinations
   Saxagliptin/ Metformin Hydrochloride
    D10263  Metformin hydrochloride and saxagliptin hydrochloride
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10263
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10263
Other DBs
PubChem: 163312294
LinkDB

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