KEGG   DRUG: Trenonacog alfa
Entry
D10401                      Drug                                   

Name
Trenonacog alfa (USAN/INN)
Formula
C2580H3960N594O1045S25
Exact mass
60782.8006
Mol weight
60820.0262
Sequence
YNSGKLEEFV QGNLERECME EKCSFEEARE VFENTERTTE FWKQYVDGDQ CESNPCLNGG
SCKDDINSYE CWCPFGFEGK NCELDVTCNI KNGRCEQFCK NSADNKVVCS CTEGYRLAEN
QKSCEPAVPF PCGRVSVSQT SKLTRAETVF PDVDYVNSTE AETILDNITQ STQSFNDFTR
VVGGEDAKPG QFPWQVVLNG KVDAFCGGSI VNEKWIVTAA HCVETGVKIT VVAGEHNIEE
TEHTEQKRNV IRIIPHHNYN AAINKYNHDI ALLELDEPLV LNSYVTPICI ADKEYTNIFL
KFGSGYVSGW GRVFHKGRSA LVLQYLRVPL VDRATCLRST KFTIYNNMFC AGFHEGGRDS
CQGDSGGPHV TEVEGTSFLT GIISWGEECA MKGKYGIYTK VSRYVNWIKE KTKLT
(Disulfide bridge: 18-23, 51-62, 56-71, 73-82, 88-99, 95-109, 111-124, 132-289, 206-222, 336-350, 361-389; Modified residue: 7-8-15-17-20-21-26-27-30-33-36-40 4-carboxyGlu; Glycosylation site: Asn-157, Asn-167)
  Type
Peptide
Class
Cardiovascular agent
 DG02016  Hemostatics
  DG02013  Blood coagulation factor
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10538<JP> D10757<JP> D10770<JP>
Efficacy
Prophylactic (hepatitis B)
Comment
blood-coagulation factor IX (148-Thr) (synthetic human isoform IB1001)
Treatment of hemophilia B
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D10401  Trenonacog alfa (USAN/INN)
Other DBs
CAS: 1232401-60-3
PubChem: 172232494
LinkDB

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