KEGG   DRUG: Bococizumab
Entry
D10621                      Drug                                   
Name
Bococizumab (USAN/INN);
Bococizumab (genetical recombination) (JAN)
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYYMHWVRQA PGQGLEWMGE ISPFGGRTNY
NEKFKSRVTM TRDTSTSTVY MELSSLRSED TAVYYCARER PLYASDLWGQ GTTVTVSSAS
TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSNFGTQTYT CNVDHKPSNT KVDKTVERKC CVECPPCPAP PVAGPSVFLF
PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV QFNWYVDGVE VHNAKTKPRE EQFNSTFRVV
SVLTVVHQDW LNGKEYKCKV SNKGLPSSIE KTISKTKGQP REPQVYTLPP SREEMTKNQV
SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPMLDSDGS FFLYSKLTVD KSRWQQGNVF
SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIS SALAWYQQKP GKAPKLLIYS ASYRYTGVPS
RFSGSGSGTD FTFTISSLQP EDIATYYCQQ RYSLWRTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H132-L214, H145-H201, H220-H'220, H224-H'224, H227-H'227, H258-H318, H364-H422, H'22-H'96, H'132-L'214, H'145-H'201, H'258-H'318, H'364-H'422, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG03128  Anti-PCSK9 antibody and siRNA
Efficacy
Antihyperlipidemic, Anti-PCSK9 antibody
  Type
Monoclonal antibody
Comment
Treatment of dyslipidemia
Target
PCSK9 [HSA:255738] [KO:K13050]
  Pathway
hsa04979  Cholesterol metabolism
Interaction
Brite
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG03128  Anti-PCSK9 antibody and siRNA
    D10621  Bococizumab
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    PCSK9
     D10621  Bococizumab (USAN/INN)
Other DBs
CAS: 1407495-02-6
PubChem: 254741582
LinkDB

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