Entry |
|
Name |
Perampanel hydrate (JAN); Fycompa (TN) |
Formula |
(C23H15N3O)3. 4H2O
|
Exact mass |
1119.4068
|
Mol weight |
1120.2152
|
Structure |

|
Class |
Neuropsychiatric agent
DG01569 AMPA receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A substrate
|
Remark |
Therapeutic category: | 1139 |
Product (DG01901): | D08964<US> D10780<JP> |
|
Efficacy |
Antiepileptic, AMPA receptor antagonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX22 Perampanel
D10780 Perampanel hydrate (JAN) <JP>
USP drug classification [BR:br08302]
Anticonvulsants
Anticonvulsants, Other
Multiple MOA
Perampanel
D10780 Perampanel hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D10780 Perampanel hydrate (JAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), non-NMDA
GRIA
D10780 Perampanel hydrate (JAN) <JP>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10780
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10780
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10780
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10780
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10780
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Other DBs |
|
LinkDB |
|
KCF data |
ATOM 85
1 C8x C 13.7779 -12.3092
2 C8x C 13.7779 -13.7079
3 C8y C 15.0367 -14.4073
4 C8y C 16.2257 -13.7079
5 C8x C 16.2257 -12.3092
6 C8x C 15.0367 -11.6098
7 C8y C 17.4846 -14.4772
8 C8x C 17.4846 -15.8760
9 C8y C 18.6735 -16.5754
10 C8x C 19.8625 -15.8760
11 N4y N 19.8625 -14.4772
12 C8y C 18.6735 -13.7779
13 C3b C 15.0367 -15.8760
14 N3a N 15.0367 -17.2748
15 C8y C 21.1214 -13.7779
16 C8x C 22.3103 -14.4073
17 C8x C 23.4993 -13.7079
18 C8x C 23.4993 -12.3092
19 C8x C 22.3103 -11.6098
20 C8x C 21.1214 -12.3092
21 C8y C 18.6735 -17.9742
22 N5x N 17.4846 -18.6036
23 C8x C 17.4846 -20.0024
24 C8x C 18.6735 -20.7018
25 C8x C 19.8625 -20.0723
26 C8x C 19.8625 -18.6735
27 O5x O 18.6735 -12.3092
28 O0 O 28.7700 -17.1500
29 C8x C 13.7779 -12.3092
30 C8x C 13.7779 -13.7079
31 C8y C 15.0367 -14.4073
32 C8y C 16.2257 -13.7079
33 C8x C 16.2257 -12.3092
34 C8x C 15.0367 -11.6098
35 C8y C 17.4846 -14.4772
36 C8x C 17.4846 -15.8760
37 C8y C 18.6735 -16.5754
38 C8x C 19.8625 -15.8760
39 N4y N 19.8625 -14.4772
40 C8y C 18.6735 -13.7779
41 O5x O 18.6735 -12.3092
42 C8y C 21.1214 -13.7779
43 C8x C 22.3103 -14.4073
44 C8x C 23.4993 -13.7079
45 C8x C 23.4993 -12.3092
46 C8x C 22.3103 -11.6098
47 C8x C 21.1214 -12.3092
48 C8y C 18.6735 -17.9742
49 N5x N 17.4846 -18.6036
50 C8x C 17.4846 -20.0024
51 C8x C 18.6735 -20.7018
52 C8x C 19.8625 -20.0723
53 C8x C 19.8625 -18.6735
54 C3b C 15.0367 -15.8760
55 N3a N 15.0367 -17.2748
56 C8x C 13.7779 -12.3092
57 C8x C 13.7779 -13.7079
58 C8y C 15.0367 -14.4073
59 C8y C 16.2257 -13.7079
60 C8x C 16.2257 -12.3092
61 C8x C 15.0367 -11.6098
62 C8y C 17.4846 -14.4772
63 C8x C 17.4846 -15.8760
64 C8y C 18.6735 -16.5754
65 C8x C 19.8625 -15.8760
66 N4y N 19.8625 -14.4772
67 C8y C 18.6735 -13.7779
68 O5x O 18.6735 -12.3092
69 C8y C 21.1214 -13.7779
70 C8x C 22.3103 -14.4073
71 C8x C 23.4993 -13.7079
72 C8x C 23.4993 -12.3092
73 C8x C 22.3103 -11.6098
74 C8x C 21.1214 -12.3092
75 C8y C 18.6735 -17.9742
76 N5x N 17.4846 -18.6036
77 C8x C 17.4846 -20.0024
78 C8x C 18.6735 -20.7018
79 C8x C 19.8625 -20.0723
80 C8x C 19.8625 -18.6735
81 C3b C 15.0367 -15.8760
82 N3a N 15.0367 -17.2748
83 O0 O 28.7700 -17.1500
84 O0 O 28.7700 -17.1500
85 O0 O 28.7700 -17.1500
BOND 90
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 1
13 7 12 1
14 3 13 1
15 13 14 3
16 11 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 9 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 12 27 2
31 29 30 2
32 30 31 1
33 31 32 2
34 32 33 1
35 33 34 2
36 29 34 1
37 32 35 1
38 35 36 2
39 36 37 1
40 37 38 2
41 38 39 1
42 39 40 1
43 35 40 1
44 31 54 1
45 54 55 3
46 39 42 1
47 42 43 2
48 43 44 1
49 44 45 2
50 45 46 1
51 46 47 2
52 42 47 1
53 37 48 1
54 48 49 2
55 49 50 1
56 50 51 2
57 51 52 1
58 52 53 2
59 48 53 1
60 40 41 2
61 56 57 2
62 57 58 1
63 58 59 2
64 59 60 1
65 60 61 2
66 56 61 1
67 59 62 1
68 62 63 2
69 63 64 1
70 64 65 2
71 65 66 1
72 66 67 1
73 62 67 1
74 58 81 1
75 81 82 3
76 66 69 1
77 69 70 2
78 70 71 1
79 71 72 2
80 72 73 1
81 73 74 2
82 69 74 1
83 64 75 1
84 75 76 2
85 76 77 1
86 77 78 2
87 78 79 1
88 79 80 2
89 75 80 1
90 67 68 2
BRACKET 1 13.0900 -21.2100 13.0900 -10.9900
1 23.9400 -10.9900 23.9400 -21.2100
1 3
ORIGINAL 1 1 2 3 4 5 6 7 8 9 10 11 12 27 15 16 17
1 18 19 20 21 22 23 24 25 26 13 14
REPEAT 1 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
1 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
1 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76
1 77 78 79 80 81 82
2 26.6000 -18.1300 26.6000 -16.1700
2 29.8900 -16.1700 29.8900 -18.1300
2 4
ORIGINAL 2 28
REPEAT 2 83 84 85
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