KEGG   DRUG: Olipudase alfa
Entry
D10820                      Drug                                   

Name
Olipudase alfa (INN);
Olipudase alfa (genetical recombination) (JAN)
Formula
C2900H4373N783O791S24
Exact mass
63590.933
Mol weight
63631.0831
Sequence
HPLSPQGHPA RLHRIVPRLR DVFGWGNLTC PICKGLFTAI NLGLKKEPNV ARVGSVAIKL
CNLLKIAPPA VCQSIVHLFE DDMVEVWRRS VLSPSEACGL LLGSTCGHWD IFSSWNISLP
TVPKPPPKPP SPPAPGAPVS RILFLTDLHW DHDYLEGTDP DCADPLCCRR GSGLPPASRP
GAGYWGEYSK CDLPLRTLES LLSGLGPAGP FDMVYWTGDI PAHDVWHQTR QDQLRALTTV
TALVRKFLGP VPVYPAVGNH ESTPVNSFPP PFIEGNHSSR WLYEAMAKAW EPWLPAEALR
TLRIGGFYAL SPYPGLRLIS LNMNFCSREN FWLLINSTDP AGQLQWLVGE LQAAEDRGDK
VHIIGHIPPG HCLKSWSWNY YRIVARYENT LAAQFFGHTH VDEFEVFYDE ETLSRPLAVA
FLAPSATTYI GLNPGYRVYQ IDGNYSGSSH VVLDHETYIL NLTQANIPGA IPHWQLLYRA
RETYGLPNTL PTAWHNLVYR MRGDMQLFQT FWFLYHKGHP PSEPCGTPCR LATLCAQLSA
RADSPALCRH LMPDGSLPEA QSLWPRPLFC
(Disulfide bridge: 43-119, 46-111, 74-85, 175-180, 181-204, 339-385, 538-542, 548-561)
  Type
Peptide
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (acid sphingomyelinase)
Comment
Enzyme replacement therapy product
Treatment of Niemann-Pick disease type A/B
Target
SMPD1* [HSA_VAR:6609v1] [HSA:6609] [KO:K12350]
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    SMPD1* [HSA_VAR:6609v1]
     D10820  Olipudase alfa (INN)
Other DBs
CAS: 927883-84-9
PubChem: 319902620
LinkDB

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